The ability to sense pain signals is closely linked to the activity of ion channels expressed in nociceptors, the first neurons that transduce noxious stimuli into pain. Among these ion channels, TREK1, TREK2 and TRAAK from the TREK subfamily of the Two-Pore-Domain potassium (K) channels, are hyperpolarizing channels that render neurons hypoexcitable. They are regulated by diverse physical and chemical stimuli as well as neurotransmitters through G-protein coupled receptor activation. Here, we review the molecular mechanisms underlying these regulations and their functional relevance in pain and migraine induction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2022.136494 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The molecular basis of pH sensing by the human fungal pathogen TOK potassium channel.
iScience
December 2024
Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Two-pore domain, outwardly rectifying potassium (TOK) channels are exclusively expressed in fungi. Human fungal pathogen TOK channels are potential antifungal targets, but TOK channel modulation in general is poorly understood. Here, we discovered that TOK (CaTOK) is regulated by extracellular pH, in contrast to TOK channels from other fungal species tested.
View Article and Find Full Text PDFIn the early stages of retinal development, a form of correlated activity known as retinal waves causes periodic depolarizations of immature retinal ganglion cells (RGCs). Retinal waves are crucial for refining visual maps in the brain's retinofugal targets and for the development of retinal circuits underlying feature detection, such as direction selectivity. Yet, how waves alter gene expression in immature RGCs is poorly understood, particularly at the level of the many distinct types of RGCs that underlie the retina's ability to encode diverse visual features.
View Article and Find Full Text PDFResearch progress of two-pore potassium channel in myocardial ischemia-reperfusion injury.
Front Physiol
October 2024
Department of Anesthesiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Article Synopsis
- Myocardial ischemia-reperfusion injury (MIRI) occurs when blood flow is restored after a heart attack, potentially causing severe arrhythmias and heart damage.
- Potassium channels, especially those in the two-pore domain (K2P) family, are gaining attention for their role in MIRI due to their unique structure and function.
- The paper reviews the different types and functions of K2P channels in the heart, focusing on subfamilies like TWIK, TREK, and TASK, and aims to uncover their involvement in MIRI for future treatments of cardiovascular diseases.
Salidroside ameliorates hypoxic pulmonary hypertension by regulating the two-pore domain potassium TASK-1 channel.
Phytomedicine
December 2024
Department of Cardiovascular Medicine of The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233000, PR China; Key Laboratory of Basic and Clinical Cardiovascular and Cerebrovascular Diseases, Bengbu Medical University, Bengbu, Anhui Province 233004, PR China. Electronic address:
Background: Hypoxic pulmonary vasoconstriction (HPV) is a reflex constriction of vascular smooth muscle. This study aims to investigate the role of Salidroside (Sal) in pulmonary arterial dilatation and the potential mechanism of Sal regulating hypoxic pulmonary hypertension in vitro and in vivo.
Methods: A rat model of hypoxic pulmonary hypertension (HPH) was constructed using hypoxic chamber.
Pulmonary arterial hypertension (PAH) is a severe disease caused by progressive distal pulmonary artery obstruction. One cause of PAH are loss-of-function mutations in the potassium channel subfamily K member 3 (KCNK3). KCNK3 encodes a two-pore domain potassium channel, which is crucial for pulmonary circulation homeostasis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!