Clinical Utility of F-FDG PET/CT in the Work-up of Children with Uveitis.

Purpose: To evaluate F-fluorodeoxyglucose Positron Emission Tomography/ultra low dose Computed Tomography (F-FDG PET/ ULD CT) in the work-up of pediatric uveitis.

Methods: Retrospective study of 12 children followed for uveitis who underwent whole body F-FDG PET/ULD CT between 2011 and 2019.

Results: The average age of the patients was 11 years. A total of 100% of patients presented with bilateral uveitis, 50% had panuveitis and 92% had various choroidal involvement. Relevant information for diagnosis was provided in four patients. 5/12 had an abnormal 18F-FDG uptake. Of these, three patients had pathognomonic images of active granulomatous diseases. Three patients underwent PET CT-guided biopsies of which two were positive for sarcoidosis.

Conclusion: F-FDG PET/CT provided important information for final diagnosis in approximately 30% (4/12) of pediatric patients with bilateral uveitis. Whole body FDG PET/ULD CT can contribute to the final diagnosis thanks to pathognomonic image of active granulomatous disease and/or by indicating metabolically active site of biopsy that would not be visualized in thorax CT.