Correction for 'Antibody-coated microstructures for selective isolation of immune cells in blood' by Jiyu Li , , 2020, , 1072-1082, DOI: 10.1039/D0LC00078G.
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Biomarkers.
Alzheimers Dement
December 2024
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Background: In the context of pathological aging and Alzheimer's disease (AD), the overexpression of calcineurin has been identified as a factor linked to astrocyte reactivity, neuronal death, and inflammation. This suggests that inhibiting calcineurin or downstream nuclear factor of activated T cells (NFAT) signaling could be a promising strategy for preventing or slowing down AD pathophysiology.
Method: Baseline and annual MRI sessions including higher-order diffusion-weighted imaging was performed over four years on 43 dogs ranging from 5 to 8.
Biomarkers.
Alzheimers Dement
December 2024
Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Background: Hippocampal atrophy is an established biomarker of neurodegeneration in Alzheimer's disease, affecting specific subfields (De Flores, La Joie and Chételat, 2015). In this study, we used 7T MRI and advanced diffusion MRI (dMRI) to investigate the relationship between hippocampal subfield volumes and microstructure and assess their sensitivity to cognitive impairment.
Method: Seventeen cognitively impaired (CI; age: 69±8, M/F: 12/5, MMSE: 28) and 22 cognitively unimpaired subjects (CU; age: 62±10, M/F: 6/16) were recruited in the context of the COSCODE project (Ribaldi et al.
Plant-based cheese analogs: structure, texture, and functionality.
Crit Rev Food Sci Nutr
January 2025
School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Plant-based cheese analogs have been developed using plant-based ingredients to mimic the appearance, structure, and flavor of conventional cheeses. Due to the complex composition and structure of cheese, developing plant-based cheese analogs that completely replicate its physicochemical, structural, sensory, and nutritional features is a highly challenging endeavor. Therefore, the design of the structure of plant-based cheese analogs requires a critical evaluation of the functional features of the selected ingredients and the specialized combination of these ingredients to create a desired structure.
View Article and Find Full Text PDFBackground: White matter (WM) damage is seen with neurodegenerative and cerebrovascular pathologies and contributes to cognitive dysfunction. We hypothesized that there are multiple disease progression patterns in WM microstructural changes related to aging and dementia, and these can be identified using SuStaIn (data-driven clustering algorithm for disease subtype and stage discovery) on multishell diffusion MRI (NODDI) data. NODDI provides information on cellular tissue architecture - neurite density index (NDI) measures packing density of axons and dendrites, and free water fraction (FWF) measures unrestricted water, e.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Structural covariance analyses have identified macrostructural/morphological alterations to MRI-based networks in behavioral variant frontotemporal dementia (bvFTD), but microstructural/neuronal alterations to histology-based networks remain unexplored. We previously found greater neurodegeneration in layers and regions enriched for pyramidal neurons in bvFTD with tau (bvFTD-tau) compared to TDP-43 (bvFTD-TDP) pathology. Therefore, we hypothesized laminar networks of empirically connected pyramidal neurons are weaker in bvFTD-tau versus bvFTD-TDP.
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