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Inpatient Infliximab Biosimilar Cost-Savings: Cost Analysis of Inpatient Treatment with Originator Infliximab (Remicade™) versus Biosimilar Infliximab (Renflexis™) for Acute Severe Ulcerative Colitis.
Dig Dis
October 2024
Division of Gastroenterology, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA.
Introduction: Infliximab (IFX) is a standard, inpatient salvage therapy for the treatment of refractory acute severe ulcerative colitis (ASUC). Remicade™ is the originator IFX. Its biosimilar Renflexis™ offers a reduced cost structure.
View Article and Find Full Text PDFA rare case of polyarthritis panniculitis and pancreatitis.
Clin J Gastroenterol
August 2024
Department of Gastroenterology, Lahey Hospital and Medical Center, 41 Burlington Mall Road, Burlington, MA, 01805, USA.
Extra pancreatic manifestations of pancreatitis are rare, with a prevalence of 2-3%. One such rare manifestation is the triad of joint pain (polyarthritis), tender skin lesions (panniculitis), and pancreatic inflammation (pancreatitis), known as PPP. The pathogenesis of this phenomenon is not fully understood but is believed to involve lipolysis by pancreatic enzymes at lipid-rich skin and joint sites.
View Article and Find Full Text PDFNosocomial spontaneous bacterial peritonitis is associated with high mortality - a systematic review and meta-analysis.
Expert Rev Gastroenterol Hepatol
December 2023
Sandra Atlas Bass Center for Liver Diseases and Transplantation, Manhasset, NY, USA.
Introduction: It is unclear if Nosocomial Spontaneous Bacteria Peritonitis (NSBP) is associated with higher mortality compared with community acquired spontaneous bacterial peritonitis.
Methods: Database search from inception to May 2022 was conducted. The databases included MEDLINE, EMBASE, Cochrane registry of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus.
Hepatic hydrothorax is not associated with increased complications or poor survival after liver transplantation.
Expert Rev Gastroenterol Hepatol
February 2023
Department of Gastroenterology, Lahey Hospital and Medical Center, Burlington, MA, USA.
Background: Hepatic hydrothorax (HH) is associated with a poor prognosis. Liver transplant (LT) is the best treatment modality. We aim to assess post-LT morbidity and mortality in patients with cirrhosis and HH.
View Article and Find Full Text PDFArticle Synopsis
- Waldenström macroglobulinemia (WM) can develop from an asymptomatic stage known as asymptomatic WM (AWM), and this study investigates the risk of progression from AWM to symptomatic WM among 439 patients.
- The research found that 72% of patients progressed to symptomatic WM over an average of 7.8 years, identifying key predictors of progression such as high immunoglobulin M levels and significant bone marrow infiltration.
- A new risk classification model was developed and validated, categorizing patients into high, intermediate, and low-risk groups for progression, which can help guide patient monitoring and potential early intervention.
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