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| http://dx.doi.org/10.1080/20961790.2021.1963515 | DOI Listing |
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The determination of biochemical parameters plays an important role in the veterinary care of alpacas, as it can provide an overview of the integrity and function of various organs and metabolic states. Various reference intervals are available for interpreting biochemical results in alpacas, but physiological variations due to age, sex or season should also be considered. Particularly, information on the influence of age is scarce.
View Article and Find Full Text PDFCardioprotective potential of tectochrysin against vanadium induced heart damage via regulating NLRP3, JAK1/STAT3 and NF-κB pathway.
J Trace Elem Med Biol
January 2025
Department of Pathology, College of Medicine, King Khalid University, Asir 61421, Saudi Arabia; Department of Forensic Medicine and Clinical Toxicology, Mansoura University, Egypt.
Background: Vanadium (VAN) is a significant trace element, but its higher exposure is reported to cause severe organ toxicity. Tectochrysin (TEC) is a naturally derived flavonoid which demonstrates a wide range of pharmacological properties.
Aim: The current study was planned to assess the cardioprotective potential of TEC against VAN induced cardiotoxicity in rats via regulating biochemical, and histological profile.
The effect of commonly employed forensic DNA extraction protocols on ssDNA/dsDNA proportion and DNA integrity.
Forensic Sci Int Genet
December 2024
Estonian Forensic Science Institute, Tallinn, Estonia.
The utilisation of massively parallel sequencing (MPS) in forensic DNA analysis is on the rise, driven by the expansion of targeted MPS panels in the market and the introduction of forensic investigative genetic genealogy. The MPS library preparation process, integral to both whole-genome sequencing (WGS) and targeted MPS panel data generation, is largely based on converting double-stranded DNA (dsDNA) into sequencing libraries. In the current study, we examined the effect of seven routinely used forensic DNA extraction methods on the strandedness (single-stranded or double-stranded) and the fragment size of the DNA extracted from buccal swab, blood, bone and tooth samples.
View Article and Find Full Text PDFBenzoylmesaconine alters the native structure and activity of hen egg white lysozyme: revealing possible mechanism of aconitum-induced toxicity.
Forensic Toxicol
December 2024
Laboratory of Forensic Biology and Biotechnology, School of Forensic Science, National Forensic Science University, Gandhinagar, Gujarat, 382007, India.
Purpose: This study examines the interaction between benzoylmesaconine (BMA) and hen egg white lysozyme (HEWL) under various physiological conditions, aiming to determine how BMA affects the HEWL's structure and function.
Methods: Several analytical techniques were used, including tryptophan assay, light scattering, thioflavin T (ThT)-binding assay, dynamic light scattering, 8-anilino-1-naphthalenesulfonic acid (ANS)-binding assay, circular dichroism (CD) spectroscopy, enzyme activity assay, and molecular docking.
Results: The tryptophan assay displayed a concentration-dependent decrease in tryptophan fluorescence, showing an interaction between BMA and HEWL.
Plug-and-Play PRNU Enhancement Algorithm with Guided Filtering.
Sensors (Basel)
December 2024
School of National Security, People's Public Security University of China, Beijing 100038, China.
As a weak high-frequency signal embedded in digital images, Photo Response Non-Uniformity (PRNU) is particularly vulnerable to interference from low-frequency components during the extraction process, which affects its reliability in real-world forensic applications. Previous studies have not successfully identified the effective frequency band of PRNU, leaving low-frequency interference insufficiently suppressed and impacting PRNU's utility in scenarios such as source camera identification, image integrity verification, and identity verification. Additionally, due to differing operational mechanisms, current mainstream PRNU enhancement algorithms cannot be integrated to improve their performance further.
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