DNA methylation and demethylation function in the balance between cellular differentiation and cancer. Although the roles of DNA methyltransferases have been extensively explored in epidermal biology, ten-eleven translocation (TET) demethylase enzymes are poorly understood. In their new article in the Journal of Investigative Dermatology, Boudra et al. present evidence for a tumor-suppressive role of TET2 and its regulation of 5-hydroxymethylcytosine in the prevention of squamous cell carcinomas.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128576 | PMC |
| http://dx.doi.org/10.1016/j.jid.2021.11.023 | DOI Listing |
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