Exp Eye Res
Department of Ophthalmology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China. Electronic address:
Published: April 2022
The activation of orbital fibroblasts can result in fibrosis, finally contributing to thyroid-associated ophthalmopathy (TAO) progression. Although the effect of BTX-A on the treatment of TAO-related strabismus and upper eyelid retraction has long been recognized in clinical work, the underlying mechanism of BTX-A improving TAO-related strabismus and upper eyelid retraction has not been uncovered yet. In the present study, we successfully isolated and authenticated normal and TAO orbital fibroblasts. Compared with PBS, BTX-A and TACA exerted similar inhibitory effects on TAO orbital fibroblast proliferation and ECM production. TGF-β stimulation induced the proliferation and ECM production by TAO orbital fibroblast, which was significantly inhibited by BTX-A or TACA treatment. Under TGF-β stimulation, the inhibitory effects of BTX-A or TACA treatment on TAO orbital fibroblast proliferation and ECM production were reversed by TGF-β/Smad signaling agonist SRI-011381. Collectively, BTX-A inhibited TGF-β-induced TAO orbital fibroblast activation through inhibiting the TGF-β/Smad signaling. Considering that TACA shows no satisfactory curative effects on symptoms closely related to the function of extraocular muscles, such as eye movement and diplopia, BTX-A might be a promising agent in TAO treatment.
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http://dx.doi.org/10.1016/j.exer.2022.108971 | DOI Listing |
J Phys Chem Lett
January 2025
Department of Physics, Rutgers University, Newark, New Jersey 07102, United States of America.
Graph Neural Networks (GNNs) have emerged as powerful tools for predicting material properties, yet they often struggle to capture many-body interactions and require extensive manual feature engineering. Here, we present EOSnet (Embedded Overlap Structures for Graph Neural Networks), a novel approach that addresses these limitations by incorporating Gaussian Overlap Matrix (GOM) fingerprints as node features within the GNN architecture. Unlike models that rely on explicit angular terms or human-engineered features, EOSnet efficiently encodes many-body interactions through orbital overlap matrices, providing a rotationally invariant and transferable representation of atomic environments.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Laboratory of Intelligent Control, Rocket Force University of Engineering, Xi'an 710025, China.
Experts and scholars from various nations have proposed studying low Earth orbit (LEO) satellite signals as the space-based signals of opportunity (SOPs) for navigation and positioning. This method serves as a robust alternative in environments where global navigation satellite systems (GNSS) are unavailable or compromised, providing users with high-precision, anti-interference, secure, and dependable backup navigation solutions. The rapid evolution of LEO communication constellations has spurred the development of SOPs positioning technology using LEO satellites.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address:
RNA-binding motif 47 (RBM47) is a recently identified RNA-binding protein involved in early vertebrate development, immune homeostasis, and cancer development. This study examined the biological functions of RBM47 in thyroid-associated ophthalmopathy (TAO). Orbital fibroblasts (OFs) were obtained from the control (n = 6) and TAO groups (n = 6).
View Article and Find Full Text PDFFront Immunol
December 2024
School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Background: Thyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue. Ferroptosis is a form of programmed cell death driven by the accumulation of reactive oxygen species (ROS), iron metabolism disorder, and lipid peroxidation. This study aims to identify and validate the optimal feature genes (OFGs) of ferroptosis with diagnostic and therapeutic potential in TAO orbital adipose tissue through bioinformatics analysis and to assess their correlation with disease-related immune cell infiltration.
View Article and Find Full Text PDFOphthalmic Plast Reconstr Surg
October 2024
Division of Oculofacial Plastic and Orbital Surgery, Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, U.S.A.
Purpose: To characterize American Society of Ophthalmic Plastic and Reconstructive Surgery (ASOPRS) fellowship graduates' career paths and contributions to society missions, including trends across gender, time, and geography.
Methods: In this retrospective cohort study, ASOPRS fellowship graduates from 2000 to 2021 were stratified by demographics, time, and geography. Main outcomes were career paths and contributions to ASOPRS missions of advancing education, research, and quality of clinical practice.
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