AI Article Synopsis
- The study investigates the link between Parkinson's disease (PD) and cardiometabolic conditions as the aging population increases the prevalence of PD.
- A case-control study analyzed data from 781 PD patients and 1,000 controls, looking at factors like diabetes, hypertension, dyslipidemia, and BMI.
- Results showed that systemic arterial hypertension (SAH) increased the risk of PD while obesity appeared to have a protective effect, suggesting a complex interaction between these conditions and PD development.
Article Abstract
Background: The prevalence of Parkinson's disease (PD) increases as the population ages. Studies have shown that some cardiometabolic comorbidities could be associated with risk or protection against developing PD. A retrospective case-control study was carried out to analyze the relationship between PD and cardiometabolic comorbidities.
Material And Methods: Subjects with PD and controls without PD were consecutively recruited. Data on type 2 diabetes mellitus, systemic arterial hypertension (SAH), dyslipidemia and body mass index were collected. Logistic regression analyses were carried out.
Results: A total of 781 subjects with PD (56.5% males) and 1,000 controls (44.4% males) were included. After adjusting for age and gender, SAH was found as an independent risk factor (OR: 1.32; 95% CI: 1.05-1.67; p = 0.02), and obesity as a protective factor (OR: 0.72; 95% CI: 0.56-0.93; p = 0.01).
Conclusions: Subjects with SAH had a higher risk of having PD, while obese subjects had a lower risk of having PD. The relationship between cardiometabolic disease, its treatment, and PD etiopathogenesis appears to be extremely complex given the amount of contradictory data.
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| http://dx.doi.org/10.24875/GMM.M21000627 | DOI Listing |
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