Prosthetic joint infection is a feared complication following elective total joint arthroplasty of the hip and knee. Infection following arthroplasty leads to high morbidity and even mortality and is a major burden to the health care system. Although many advances are being made in the treatment of prosthetic joint infection, with the increasing volume of total joint arthroplasty anticipated over the next decade, a significant emphasis should be placed on prevention. Several preoperative, intraoperative, and postoperative strategies may be employed to help reduce the risk. (Journal of Surgical Orthopaedic Advances 30(4):202-206, 2021).
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