AI Article Synopsis
- The study explored how Extracellular Vesicles (EV) from mouse embryonic fibroblasts affect wound healing in diabetic mice, utilizing both lab and live mouse experiments.
- EV isolated from the fibroblasts improved levels of key healing-related biomarkers like VEGF, IL-6, and TNF-α, enhancing blood vessel formation (angiogenesis) in the wound area.
- Results suggested that these EVs not only speed up wound healing in diabetes but also improve the delivery of crucial cells, oxygen, and nutrients to the damaged tissue.
Article Abstract
This study aimed to investigate the effects of Extracellular Vesicles (EV) secreted from mouse embryonic fibroblasts EV on wound healing of full-thickness skin defect in a diabetic mouse model. The study included both in vitro and in vivo experimental studies 82 mice. In the in vitro stage of the experimental study, hysterectomy was performed on two mice between the 13-14th days of pregnancy and then EV was isolated by cell culturing. VEGF, IL-6, and TNF-α biomarkers were examined in tissue homogenate. Moreover, tissue taken from wound area was also subjected to histopathologic scoring. EV augmented the effect of VEGF. Therefore promoted angiogenesis increases the transport of cells, essential oxygen and nutrients in the wound area. Extracellular vesicles isolated from mouse embryonic fibroblasts have been found to accelerate wound healing in diabetes. The findings obtained from this experimental study indicate that EV isolated from mouse embryonic fibroblasts accelerate the wound healing process in experimentally induced-diabetes in mice.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/0001-3765202120201562 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!