Analyzing the δH values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δH than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that "you are what you eat".
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855419 | PMC |
| http://dx.doi.org/10.1021/jacs.1c12512 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oregano essential oil-infused mucin microneedle patch for the treatment of hypertrophic scar.
Int J Pharm
November 2024
Department of Pharmaceutics and Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases of Henan Province, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, PR China. Electronic address:
Hypertrophic scar (HS) manifests as abnormal dermal myofibroblast proliferation and excessive collagen deposition, leading to raised scars and significant physical, psychological, and financial burdens for patients. HS is difficult to cure in the clinic and current therapies lead to recurrence, pain, and side effects. In this study, a natural amphiphilic polymer mucin is used to prepare a dissolving microneedle (muMN) that is loaded with oregano essential oil (OEO) for HS therapy.
View Article and Find Full Text PDFIs Exon Skipping a Viable Therapeutic Approach for Vascular Ehlers-Danlos Syndrome with Mutations in Exon 10 or 15?
Int J Mol Sci
August 2024
Centre of Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA 6150, Australia.
Article Synopsis
- - Vascular Ehlers-Danlos syndrome (vEDS) is a serious connective tissue disorder marked by skin elasticity issues, joint hypermobility, and risks of deadly vascular ruptures due to specific collagen III mutations.
- - The study investigated using antisense oligonucleotides (ASOs) to modify pre-mRNA and bypass these mutations, leading to successful excision of specific exons (10 and 15) and increased collagen III expression in patient fibroblasts.
- - Although the ASOs effectively skipped the target exons, the resulting collagen III showed problems with extracellular matrix formation, indicating that post-translational modifications are critical to proper collagen assembly and raising questions about the approach's therapeutic potential. *
DaiTongXiao improves gout nephropathy by inhibiting inflammatory response through the TLR4/MyD88/NF-κB pathway.
Front Pharmacol
August 2024
College of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan, China.
Article Synopsis
- Gouty nephropathy (GN) is a kidney condition caused by high uric acid levels due to factors like excessive purine intake and metabolic disorders, leading to crystal buildup in kidney tissue.
- DaiTongXiao (DTX), a traditional remedy from the Dai people in China, shows promise in reducing uric acid levels and has anti-inflammatory and kidney-protective effects.
- In a rat model of GN, DTX treatment improved kidney function and structure, decreased serum inflammatory markers, and inhibited the TLR4/MyD88/NF-κB signaling pathway, indicating its potential as a therapeutic option for GN.
Eight hydroxyproline-O-galactosyltransferases play essential roles in female reproductive development.
Plant Sci
November 2024
LAQV Requimte, Sustainable Chemistry, Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Porto 4169-007, Portugal. Electronic address:
In angiosperms, ovules give rise to seeds upon fertilization. Thus, seed formation is dependent on both successful ovule development and tightly controlled communication between female and male gametophytes. During establishment of these interactions, cell walls play a pivotal role, especially arabinogalactan-proteins (AGPs).
View Article and Find Full Text PDFVinpocetine and Lactobacillus improve fatty liver in rats: role of adiponectin and gut microbiome.
AMB Express
August 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Damanhour University, Damanhour, 22511, Egypt.
Therapeutics that interfere with the damage/pathogen-associated molecular patterns (DAMPs/PAMPs) have evolved as promising candidates for hepatic inflammation like that occurring in non-alcoholic fatty liver disease (NAFLD). In the current study, we examined the therapeutic impact of the phosphodiesterase-1 inhibitor vinpocetine (Vinpo), alone or when combined with Lactobacillus, on hepatic abnormalities caused by a 13-week high-fat diet (HFD) and diabetes in rats. The results show that Vinpo (10 and 20 mg/kg/day) dose-dependently curbed HFD-induced elevation of liver injury parameters in serum (ALT, AST) and tissue histopathology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!