Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891548 | PMC |
| http://dx.doi.org/10.1111/cpr.13197 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The metabaging cycle promotes non-metabolic chronic diseases of ageing.
Cell Prolif
October 2024
Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review.
J Cachexia Sarcopenia Muscle
April 2022
Department of Health Education, Shijingshan Center for Disease Prevention and Control, Beijing, China.
Age-associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing, adipose inflammation leads to the redistribution of fat to the intra-abdominal area (visceral fat) and fatty infiltrations in skeletal muscles, resulting in decreased overall strength and functionality. Lipids and their derivatives accumulate both within and between muscle cells, inducing mitochondrial dysfunction, disturbing β-oxidation of fatty acids, and enhancing reactive oxygen species (ROS) production, leading to lipotoxicity and insulin resistance, as well as enhanced secretion of some pro-inflammatory cytokines.
View Article and Find Full Text PDFThe Metabaging Cycle.
Cell Prolif
March 2022
State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences, Beijing, China.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!