AI Article Synopsis
- Youth with Klinefelter syndrome (KS) show higher prevalence rates of cardiometabolic issues compared to matched controls, specifically in areas like overweight/obesity, dyslipidemia, and liver dysfunction.
- The study analyzed health records from 6 pediatric institutions, comparing 1080 youth with KS and 4497 matched controls based on various demographic factors.
- Adjusting for factors like obesity and treatment did reduce the observed effects, but boys with KS still exhibited significantly greater odds for overweight/obesity and liver dysfunction when compared to control groups.
Article Abstract
Context: Diabetes and cardiovascular diseases are common among men with Klinefelter syndrome (KS) and contribute to high morbidity and mortality.
Objective: To determine if cardiometabolic-related diagnoses are more prevalent among youth with KS than matched controls in a large population-based cohort.
Methods: Secondary data analysis of electronic health records from 6 pediatric institutions in the United States (PEDSnet). Patients included all youth with KS in the database (n = 1080) and 4497 youth without KS matched for sex, age (mean 13 years at last encounter), year of birth, race, ethnicity, insurance, site, and duration of care (mean 7 years). The main outcome measures were prevalence of 5 cardiometabolic-related outcomes: overweight/obesity, dyslipidemia, dysglycemia, hypertension, and liver dysfunction.
Results: The odds of overweight/obesity (OR 1.6; 95% CI 1.4-1.8), dyslipidemia (3.0; 2.2-3.9), and liver dysfunction (2.0; 1.6-2.5) were all higher in KS than in controls. Adjusting for covariates (obesity, testosterone treatment, and antipsychotic use) attenuated the effect of KS on these outcomes; however, boys with KS still had 45% greater odds of overweight/obesity (95% CI 1.2-1.7) and 70% greater odds of liver dysfunction (95% CI 1.3-2.2) than controls, and both dyslipidemia (1.6; 1.1-2.4) and dysglycemia (1.8; 1.1-3.2) were higher in KS but of borderline statistical significance when accounting for multiple comparisons. The odds of hypertension were not different between groups.
Conclusion: This large, population-based cohort of youth with KS had a higher odds of most cardiometabolic-related diagnoses than matched controls.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272432 | PMC |
| http://dx.doi.org/10.1210/clinem/dgac056 | DOI Listing |
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