COVID 19 has exacerbated and underscored structural inequalities and endemic vulnerabilities in food, economic, and social systems, compounding concerns about environmental sustainability and racial and economic justice. Convergent crises have amplified a growing chorus of voices and movements calling for new thinking and new practices to adapt to these shifts, mitigate their impact, and address their root causes through far reaching changes in social and economic life and values, including breaking with the free market paradigm. In the face of a historic choice between transition or multiple systems collapse that deepen injustice and threaten planetary survival, I make the case for expanding on liberatory tendencies in Extension programs to build capacities for response-ability to transition toward more just and sustainable futures.
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http://dx.doi.org/10.1007/s10460-022-10295-5 | DOI Listing |
Int J Biol Macromol
December 2024
Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur 603203, Chengalpattu District, Tamil Nadu, India. Electronic address:
The development of targeted nanotherapeutics has emerged as a pivotal advancement in cancer treatment, aiming to enhance the efficacy and specificity of drug delivery while minimizing systemic toxicity. Due to their biocompatibility and modifiable surface properties, Chitosan-based nanoparticles have shown considerable promise in encapsulating and delivering therapeutic agents directly to tumor sites. This study investigates the potential of 1,5-diary pyrazole derivative (T4)-loaded chitosan (CS) nanoparticles as a novel anticancer agent, evaluating their physical characteristics, in vivo biodistribution, and therapeutic efficacy against cancerous cells.
View Article and Find Full Text PDFMedComm (2020)
November 2024
Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Disease Research Beijing China.
IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis, resulting in end-stage renal disease and increased mortality rates. Prognostic biomarkers reflecting molecular mechanisms for effective IgAN management are urgently needed. Analysis of kidney single-cell transcriptomic sequencing data demonstrated that IgAN expressed high-expression levels of inflammatory cytokines TNFSF10, TNFSF12, CCL2, CXCL1, and CXCL12 than healthy controls (HCs).
View Article and Find Full Text PDFSurg Technol Int
October 2024
Department of Digestive, Hepatobiliary, and Liver Transplantation Surgery, AP-HP, Hôpital de la Pitié-Salpêtrière, Paris, France.
While metastatic extension to the cardiophrenic lymph nodes (CPN) is relatively rare, cardiophrenic lymphadenectomy may be performed for diagnostic and/or therapeutic purposes. The subxiphoid approach is appropriate, especially for CPN in the prepericardiac area, offering adequate exposure while avoiding the morbidity associated with pleural or pericardial breach. In this article, we describe the surgical technique-detailing the retrosternal liberation section of the tranversus abdominis muscle, followed by cardiophrenic dissection and lymphadenectomy.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
October 2024
Instituto Carlos Roxo, Rio de Janeiro, Brazil.
Pharm Dev Technol
November 2024
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain.
Aim: Oral candidiasis is often challenging due to limited effectiveness of topical treatments. This study aimed to develop novel caspofungin formulations for administration onto the oral mucosa to enhance drug retention and efficacy.
Method: Five caspofungin (2%, w/v) formulations were developed to assess their permeability, retention and mucoadhesiveness.
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