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A phase I study using bortezomib (Velcade), cladribine, and rituximab in treating patients over 50 years old with mantle cell lymphoma.
Front Oncol
December 2024
Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA, United States.
Article Synopsis
- Cladribine reduces DNA, RNA, and histone methylation and works well with rituximab to treat B-cell lymphomas.
- A phase I study found that combining bortezomib, cladribine, and rituximab is safe and effective for elderly patients with mantle cell lymphoma, with an overall response rate of 84.6%.
- The treatment shows promising outcomes, including high complete remission rates and identified DNA methylation biomarkers that may indicate effective responses.
Brexucabtagene autoleucel in-vivo expansion and BTKi refractoriness have a negative influence on progression-free survival in mantle cell lymphoma: Results from CART-SIE study.
Br J Haematol
December 2024
Hematology, School of Medicine, Università degli Studi di Milano, Milan, Italy.
Brexucabtagene autoleucel (brexu-cel) has revolutionized the treatment of patients affected by mantle cell lymphomas. In this prospective, observational multicentre study, we evaluated 106 patients, with longitudinal brexu-cel kinetics in peripheral blood monitored in 61 of them. Clinical outcomes and toxicities are consistent with previous real-world evidence studies.
View Article and Find Full Text PDFGenomic mechanisms associated with resistance to PDL1-blockade in a patient with mantle cell lymphoma.
Leuk Lymphoma
December 2024
Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia.
The survival grip-how cell adhesion promotes tumor maintenance within the microenvironment.
FEBS Lett
December 2024
INSERM U978, Bobigny, France.
Cell adhesion is warranted by proteins that are crucial for the maintenance of tissue integrity and homeostasis. Most of these proteins behave as receptors to link adhesion to the control of cell survival and their expression or regulation are often altered in cancers. B-cell malignancies do not evade this principle as they are sustained in relapsed niches by interacting with the microenvironment that includes cells and their secreted factors.
View Article and Find Full Text PDFInfected Primary Bone Mantle Cell Lymphoma with Multiple Vertebral Involvement.
Int J Hematol Oncol Stem Cell Res
October 2024
Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital, Mahdia, Tunisia.
Primary vertebral lymphoma is an exceedingly rare entity. We hereby report a case of a 67-year-old male who presented to our department with fever, weight loss, and progressively worsening lower back pain radiating to the right hip. Physical examination showed pain on percussion of the dorsal and lumbar spine and tenderness on palpation of the right upper thigh area.
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