AI Article Synopsis
- Cardiovascular diseases are the leading cause of global mortality, and interleukin-6 (IL-6) serves as a key biomarker for assessing cardiovascular risk.
- The study analyzed the IL-6 levels in 2809 participants from the 1982 Pelotas Birth Cohort, focusing on factors from early life to age 30, such as ancestry, income, education, smoking, and body composition.
- Results indicated that low education and smoking increased IL-6 levels in males, while African ancestry and low income affected females; overall, body composition was the strongest predictor of IL-6 concentrations, highlighting the need to manage weight for cardiovascular health.
Article Abstract
Background: Cardiovascular diseases are the main cause of death globally. Interleukin-6 (IL-6) is a biomarker of cardiovascular risk.
Aim: To investigate factors associated with IL-6 concentration in serum, from early life up to 30 years of age.
Subjects And Methods: In the 2012-2013 follow-up, IL-6 was measured in 2809 participants of the 1982 Pelotas Birth Cohort (1369 males). Multivariable linear regressions, stratified by sex, were performed to evaluate the associations of African ancestry, family income and maternal education at birth, monthly income and education at 30 years, smoking status, harmful alcohol intake, physical activity, and body composition with IL-6, considering a conceptual hierarchical framework.
Results: Males with low educational levels and current smokers had the highest mean IL-6. Among females, African ancestry and low monthly income were associated with the highest mean values for the outcome. Physical activity had an inverse association with IL-6 concentration among females. A direct relationship was observed between the measures of adiposity on IL-6, in both sexes.
Conclusion: Body composition was the main predictor for the outcome evaluated in males and females. Thus, the avoidance of overweight remains an important strategy for the prevention and control of cardiovascular risk and biomarkers associated with these diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/03014460.2021.1998619 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Gender Gap for Accelerometry-Based Physical Activity Across Different Age Groups in 5 Brazilian Cohort Studies.
J Phys Act Health
November 2024
Postgraduate Program in Physical Education and Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil.
Objectives: This study aims to evaluate the gender inequalities in accelerometer-based physical activity (PA) across different age groups using data from 5 Pelotas (Brazil) cohorts.
Methods: The data come from 4 birth cohort studies, covering all live births in the urban area of Pelotas for each respective year (1982, 1993, 2004, and 2015), and the Como vai? cohort study focusing on 60 years and above. Raw accelerometry data were collected on the nondominant wrist using GENEActive/ActiGraph devices and processed with the GGIR package.
Socioeconomic status in life course is associated with dental appearance dissatisfaction.
Braz Oral Res
June 2024
Universidade Federal de Pelotas - UFPel, Graduate Program in Dentistry and Epidemiology, Pelotas, RS, Brazil.
The present study aimed to investigate the prevalence of dissatisfaction with dental appearance among 24-year-old Brazilian adults and the associated factors in life course. A subsample (n = 720) of the 1982 Pelotas Birth Cohort in southern Brazil was investigated at the ages of 15 and 24 years using clinical (caries and periodontal) examinations and interviews. The outcome was dissatisfaction with dental appearance at the age of 24 years.
View Article and Find Full Text PDFDifferential effect of social mobility on tooth loss by race in adulthood: 1982 Pelotas Birth Cohort Study.
Community Dent Oral Epidemiol
October 2024
Graduate Program in Dentistry, Universidade Federal de Pelotas, Pelotas, Brazil.
Article Synopsis
- The study investigates how social mobility affects tooth loss in adults from a specific birth cohort, focusing on race as a potential modifying factor.
- Data from 541 participants revealed that 50.8% experienced tooth loss, and within the "never poor" social mobility group, Black/Brown individuals had significantly higher rates of tooth loss compared to whites.
- Results indicate that social mobility and race interact in complex ways, showing greater tooth loss prevalence in downwardly mobile groups and highlighting racial inequities especially among those who were never poor.
[Association between birth conditions and bone mineral density in adults from the 1982 and 1993 birth cohorts in Pelotas, Rio Grande do Sul State, Brazil].
Cad Saude Publica
March 2024
Universidade Federal de Pelotas, Pelotas, Brasil.
This study assessed the association of birth weight, gestational age, and intrauterine growth with bone mineral density (BMD) at 22 and 30 years of age in the 1982 and 1993 birth cohorts in Pelotas, Rio Grande do Sul State, Brazil. BMD was measured by dual-energy X-ray absorptiometry (DXA) and the association was assessed using analysis of variance. Multiple linear regression was used to control for confounding factors: sex; household income at birth; maternal smoking during pregnancy; maternal schooling; maternal ethnicity/skin color; and pre-pregnancy body mass index.
View Article and Find Full Text PDFInvestigating changes in IQ scores over a decade in Brazil: factors at play.
Soc Psychiatry Psychiatr Epidemiol
February 2024
Universidade Federal de Pelotas, Pelotas, Brazil.
Purpose: This study aimed to determine whether the factors underlying potential differences between two birth cohorts, born in 1982 and 1993, influence the changes in IQ over time.
Methods: Data from two Brazilian birth cohorts were used (1993 and 1982 Pelotas Birth Cohorts). The IQ scores were assessed using the WAIS-III test.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!