High expression of PIN1 is associated with gastric cancer progression and risk. Two single-nucleotide polymorphisms in , rs2233678 and rs2233679, were examined in gastric cancer patients using PCR-restriction fragment length polymorphism. The rs2233678 GC genotype and C alleles correlated with a decreased susceptibility to gastric cancer. The stratification analysis indicated that the rs2233678 GC genotype was inversely related to gastric cancer risk in never smokers, never drinkers and patients with stage I/II disease. Males and ever drinkers carrying the rs2233679 CT genotype had a mildly elevated susceptibility to gastric cancer. The single-nucelotide polymorphisms rs2233678 and rs2233679 correlate with the risk of gastric cancer.
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