We present a multichannel setup capable of generating high peak power tunable duration pulses. Our architecture is based on a configurable RLC circuit and allows generation of 1120 current pulses, with the variable duration spanning 14-212 µs with 1 µs resolution and the peak current reaching 500 A. We use silicon controlled rectifier based multiplexing to deliver current pulses to dedicated inductors that generate 0.8 T strong magnetic fields that create a moving magnetic trap for paramagnetic particles in a supersonic beam.
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http://dx.doi.org/10.1063/5.0077604 | DOI Listing |
Methods Mol Biol
January 2025
Genes & Human Disease Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
ChIP-Seq is used to study DNA-protein interactions, unraveling chromatin states and gene regulatory properties of transcription factors. ChIP-Seq involves immunoprecipitation followed by sequencing using Next-Generation sequencing approaches. The ENCODE consortium provides extensive guidelines for ChIP-Seq analysis.
View Article and Find Full Text PDFAnal Chem
January 2025
Institute of Artificial Intelligence, Xiamen University, Xiamen, Fujian, 361005, China.
Metabolite identification from 1D H NMR spectra is a major challenge in NMR-based metabolomics. This study introduces NMRformer, a Transformer-based deep learning framework for accurate peak assignment and metabolite identification in 1D H NMR spectroscopy. Unlike traditional approaches, NMRformer interprets spectra as sequences of spectral peaks and integrates a self-attention mechanism and peak height ratios directly into the Transformer encoder layer.
View Article and Find Full Text PDFACS Chem Neurosci
January 2025
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, United States.
Receptor interacting protein kinase 1 (RIPK1) crucially upregulates necroptosis and is a key driver of inflammation. An effective PET radioligand for imaging brain RIPK1 would be useful for further exploring the role of this enzyme in neuroinflammation and for assisting drug discovery. Here, we report our progress on developing a PET radioligand for RIPK1 based on the phenyl-1-dihydropyrazole skeleton of a lead RIPK1 inhibitor, GSK'963.
View Article and Find Full Text PDFJ Cancer
January 2025
Department of Mechanical Engineering, National Chung Cheng University, Chia-Yi 62102, Taiwan.
Band selection is a common approach to reduce the data dimensionality of hyperspectral imagery. It extracts several bands of importance in some sense by taking advantage of high spectral correlation. In medical imaging, narrow-band imaging (NBI) is an imaging technique for endoscopic diagnostic medical tests, where light of specific blue and green wavelengths is used to enhance the detail of certain aspects of the surface of the mucosa.
View Article and Find Full Text PDFACS Appl Nano Mater
December 2024
Assistant Professor of Material Science and Engineering, School for Engineering of Matter, Transport and Energy (SEMTE), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Tempe, Arizona 85287, United States.
Additive manufacturing known as 3D printing has transformed the material landscape, with intricate structures and rapid prototyping for modern production. While nanoscale 3D printing has made significant progress, a critical challenge remains in the rapid, high-throughput tailoring of complex nanostructures. Here, we present a 3D printing-facilitated, light-driven assembly technology for rapid surface patterning consisting of complex particle nanonetworks with balanced fabrication resolution and processing scalability.
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