This overview summary of the Informatics Section of the book Transforming biomedical informatics and health information access: Don Lindberg and the U.S. National Library of Medicine illustrates how the NLM revolutionized the field of biomedical and health informatics during Lindberg's term as NLM Director. Authors present a before-and-after perspective of what changed, how it changed, and the impact of those changes.
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http://dx.doi.org/10.3233/SHTI210976 | DOI Listing |
Nat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDFFront Educ (Lausanne)
August 2024
Center for the Advancement of Science Leadership and Culture, Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
Genet Med Open
June 2024
Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, WA.
Purpose: We developed an electronic patient-facing family history collection tool including B-RST 3.0, PREMM risk assessments and "limited family knowledge/structure" information designed for primary care settings. We evaluated the tool's performance compared with genetic-counselor-collected information for clinical risk stratification in a population with barriers to access.
View Article and Find Full Text PDFAnn Work Expo Health
December 2024
Division of Respiratory Health, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV, United States.
BJS Open
October 2024
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Background: There are differences in oesophageal cancer care across Sweden. According to national guidelines, all patients should be offered equal care, planned and administrated by regional multidisciplinary team meetings. The aim of the study was to investigate differences between regional multidisciplinary team meetings in Sweden regarding clinical staging and treatment recommendations for oesophageal cancer patients.
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