AI Article Synopsis
- Calprotectin is a protein released by neutrophils that serves as a sensitive marker for neutrophil-mediated inflammation, particularly in bacterial infections.
- The study aimed to investigate how quickly calprotectin levels rise compared to other inflammatory markers like CRP, IL-6, TNF-α, and procalcitonin after a mild inflammatory response from inguinal hernia surgery.
- Findings indicated that calprotectin levels rose significantly within 2 hours post-surgery, peaking at 24-36 hours, while other markers showed delayed responses, suggesting calprotectin could be valuable for early detection of inflammation.
Article Abstract
Calprotectin is one of the most abundant proteins of neutrophil granulocytes. It is released upon neutrophil activation and is considered a sensitive and clinically useful marker for neutrophil-mediated inflammation, including bacterial infections. However, early kinetics of calprotectin activation following inflammatory activation has hitherto been unknown. The aim of the present study was to determine the early phase of the kinetics of calprotectin, in comparison with the inflammatory markers CRP, IL-6, TNF-α, and procalcitonin, in plasma following a standardized temporary mild inflammatory response, using uncomplicated inguinal hernia surgery as a model. The study cohort consisted of 17 adult patients (15 male and 2 female) undergoing elective surgery for hernia. Values of calprotectin increased significantly at 2 h following surgery, and continued to increase to reach the highest level at 24-36 h after surgery, values still not exceeding upper normal reference level. This contrasts to IL-6 and CRP, for which an elevation was found first later, 4 h and 24-36 h post-surgery, respectively, for IL-6, and CRP. No significant increase was seen for TNF-α, or procalcitonin. The data demonstrate a very rapid and significant but modest increase in calprotectin following induction of mild inflammation, supporting that calprotectin can be useful for early detection of inflammatory response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8841635 | PMC |
| http://dx.doi.org/10.1177/17534259211069635 | DOI Listing |
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