AI Article Synopsis
- Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, often developing from chronic liver damage, inflammation, and resulting conditions like fibrosis and cirrhosis.
- Preclinical mouse models are essential for exploring the molecular mechanisms of HCC and testing new treatments due to their reliability and versatility.
- A variety of mouse models have been created using different methods, such as chemical agents, genetic modifications, special diets, and tumor cell transfers, highlighting the importance of selecting the right model to mimic the genetic and physiological characteristics of human HCC.
Article Abstract
Hepatocellular carcinoma (HCC) is by far the most common histological subtype of primary liver cancer. HCC often originates from chronic liver injuries and inflammation, subsequently leading to fibrosis and cirrhosis. Preclinical animal models, especially mice, are viewed as valuable and reliable tools for investigating the molecular processes involved in hepatocarcinogenesis and facilitating the evaluations of the efficacy of novel therapies for HCC. A wide range of mouse models of HCC has been established using various approaches including chemotoxic agents, genetic modifications, special diet administration, and tumor cells transplantation. Choosing a suitable model to represent certain genetic and physiological features of human HCC seems to be crucial. Here, we review the current preclinical mouse models that are frequently used to study HCC.
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| http://dx.doi.org/10.1016/j.yexcr.2022.113042 | DOI Listing |
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