AI Article Synopsis
- Centrosomes are crucial for organizing mitotic spindles during cell division and duplicate once for accurate mitosis.
- Research on Drosophila's centrocortin (cen) has shown it is necessary for proper centrosome separation but its role in centriole duplication was unclear.
- Time-lapse recordings reveal that while cen is not essential for centriole duplication, it plays a significant role in ensuring centrosomes separate correctly.
Article Abstract
Centrosomes are microtubule-organizing centers that duplicate exactly once to organize the bipolar mitotic spindle required for error-free mitosis. Prior work indicated that Drosophila centrocortin (cen) is required for normal centrosome separation, although a role in centriole duplication was not closely examined. Through time-lapse recordings of rapid syncytial divisions, we monitored centriole duplication and the kinetics of centrosome separation in control vs cen null embryos. Our data suggest that although cen is dispensable for centriole duplication, it contributes to centrosome separation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9210305 | PMC |
| http://dx.doi.org/10.1093/g3journal/jkab434 | DOI Listing |
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