AI Article Synopsis
- A bioinspired approach was developed for the total synthesis of spiroaxillarone A, a compound showing strong antimalarial effects against resistant strains (IC = 2.32 μM).
- The synthesis involves important reactions such as an intermolecular ethanethiol Michael addition and a -quinone Michael addition, followed by a β-ethanethiol elimination.
- This synthetic method not only achieves the target compound but also suggests a potential biosynthetic pathway for spiroaxillarone A.
Article Abstract
A bioinspired strategy is described for the total synthesis of spiroaxillarone A, which exhibited significant antimalarial activity against resistant (IC = 2.32 μM). The key steps include an intermolecular ethanethiol Michael addition, -quinone Michael addition, and subsequent β-ethanethiol elimination. This synthetic sequence provides a potential biosynthetic pathway of spiroaxillarone A.
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| http://dx.doi.org/10.1021/acs.orglett.1c04282 | DOI Listing |
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