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Dynole 34-2 and Acrylo-Dyn 2-30, Novel Dynamin GTPase Chemical Biology Probes. | LitMetric

AI Article Synopsis

  • - The protocol outlines the chemical synthesis process for two dynamin inhibitors, Dynole 34-2 and Acrylo-Dyn 2-30, along with their chemically similar inactive counterparts.
  • - The active and inactive compounds are closely related, making it easier to synthesize three of the four compounds from a shared intermediate.
  • - The synthesis and assay data enable researchers to study the effects of these compounds on dynamin both in laboratory settings (in vitro) and potentially in living organisms (in vivo).

Article Abstract

This protocol describes the chemical synthesis of the dynamin inhibitors Dynole 34-2 and Acrylo-Dyn 2-30, and their chemical scaffold matched partner inactive compounds. The chosen active and inactive paired compounds represent potent dynamin inhibitors and very closely related dynamin-inactive compounds, with the synthesis of three of the four compounds readily possible via a common intermediate. Combined with the assay data provided, this allows the interrogation of dynamin in vitro and potentially in vivo.

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Source
http://dx.doi.org/10.1007/978-1-0716-1916-2_17DOI Listing

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