AI Article Synopsis
- The study aimed to identify significant genetic associations by comparing genetic information of varicose vein patients with healthy individuals.
- The research involved collecting clinical and demographic data from patients and analyzing their genetic samples against a database of sex-matched healthy controls.
- The results revealed six significant single nucleotide polymorphisms (SNPs) linked to different genes, suggesting potential areas for further investigation in understanding varicose veins.
Article Abstract
Background: The aim was to compare the genetic information of varicose vein patients with that of a healthy population attempting to identify certain significant genetic associations.
Method: Patients' clinical characteristics and demographics were collected, and their genetic samples were examined. The results were compared to the genetic information of one thousand sex-matched healthy controls from Taiwan Biobank database. The Clinical-Etiology-Anatomy-Pathophysiology classification was applied for further subgroup analysis.
Results: After comparison of genetic information of ninety-six patients to that of healthy controls, two significant single nucleotide polymorphisms (SNPs) were identified. One was in DPYSL2 gene, and the other was in VSTM2L gene. A further comparison between C2-3 patient subgroup and C4-6 subgroup identified another four significant SNPs, which were located in ZNF664-FAM101A, PHF2, ACOT11, and TOM1L1 genes.
Conclusion: Our preliminary result identified six significant SNPs located in six different genes. All of them and their genetic products may warrant further investigations.
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| http://dx.doi.org/10.1177/02683555211069248 | DOI Listing |
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