Treatment of renal angiomyolipoma (AML) seeks to reduce related complications and preserve kidney function. The purpose of this article was to perform an updated literature review on the diagnosis, therapeutic options, and criteria for invasive intervention in patients with renal AML. Computerized tomography is the standard diagnostic method for renal AML, while definitive diagnosis is made by histopathology. The management of choice in most cases is active surveillance (AS), with a clinical and imaging follow-up protocol. In high-risk cases, therapeutic management should be considered, with alternatives such as selective arterial embolization (SAE), nephron-sparing surgery (NSS), and mTOR inhibitors in selected patients. Renal AML in women of childbearing age, those with growth >0.25 cm/year, intralesional aneurysms >5 mm, and clinically significant symptoms may qualify for active treatment. Despite the limitations derived from the available evidence, it is possible to consider SAE, NSS, and the use of mTOR inhibitors as management alternatives for selected patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792032 | PMC |
| http://dx.doi.org/10.15586/jkcvhl.v9i1.177 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Therapeutic Potential of Oral Everolimus for Facial Angiofibromas in Pediatric Tuberous Sclerosis Complex: A Case-Based Analysis of Efficacy.
Diseases
December 2024
Department of Pediatrics, Dokkyo Medical University, Tochigi 321-0293, Japan.
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mutations in the TSC1 and TSC2 genes, leading to the dysregulation of the mammalian target of rapamycin (mTOR) pathway. This dysregulation results in the development of benign tumors across multiple organ systems and poses significant neurodevelopmental challenges. The clinical manifestations of TSC vary widely and include subependymal giant cell astrocytomas (SEGAs), renal angiomyolipomas (AMLs), facial angiofibromas (FAs), and neuropsychiatric conditions such as autism spectrum disorder (ASD).
View Article and Find Full Text PDFPredicting Bleeding Related Events in Robotic-Assisted Partial Nephrectomy for Angiomyolipoma: Simplifying Risk Assessment with Tumor Diameter and Depth, A Retrospective Study.
Ther Clin Risk Manag
December 2024
Department of Medicine, Chang Gung University, Taoyuan City, Taiwan.
Background: Evaluating risk factors for bleeding events in robot-assisted partial nephrectomy (RAPN) for renal angiomyolipoma (RAML) is essential for improving surgical outcomes.
Methods: We performed a retrospective analysis of patients who underwent RAPN for renal masses between May 2019 and June 2023 at a single medical center, categorizing them into AML and non-AML groups. We assessed demographic data, perioperative complications, and postoperative outcomes.
Pediatric Renal Cell Carcinoma (pRCC) Subpopulation Environmental Differentials in Survival Disadvantage of Black/African American Children in the United States: Large-Cohort Evidence.
Cancers (Basel)
November 2024
Global Health Equity Foundation, Bear, DE 19701, USA.
Article Synopsis
- Pediatric renal cell carcinoma (pRCC) is a rare, aggressive cancer in children with lower survival rates compared to other pediatric cancers, influenced by factors like sex, race, ethnicity, age, and socio-economic status.
- A retrospective study analyzed 174 pRCC cases from 1973 to 2015 to understand survival rates, identifying significant disparities, such as black/AA children being nearly three times more likely to die from the disease than white children.
- The study highlights the need for further research into socio-economic and demographic factors affecting pRCC outcomes, as well as exploring insufficiently studied determinants like area of residence.
A noninvasive comprehensive model based on medium sample size had good diagnostic performance in distinguishing renal fat-poor angiomyolipoma from homogeneous clear cell renal cell carcinoma.
Urol Oncol
December 2024
Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China; Key Laboratory of Medical Imaging of Gansu Province, Lanzhou University Second Hospital, Lanzhou, China; Second Clinical School, Lanzhou University, Lanzhou, China; Gansu International Scientific and Technological Cooperation Base of Medical Imaging Artificial Intelligence, Lanzhou, China. Electronic address:
Purpose: To determine the diagnostic value of a comprehensive model based on unenhanced computed tomography (CT) images for distinguishing fat-poor angiomyolipoma (fp-AML) from homogeneous clear cell renal cell carcinoma (hm-ccRCC).
Methods: We retrospectively reviewed 27 patients with fp-AML and 63 with hm-ccRCC. Demographic data and conventional CT features of the lesions were recorded (including sex, age, symptoms, lesion location, shape, boundary, unenhanced CT attenuation and so on).
Wearable Accelerometer-Derived Measures of Physical Activity in Heart Failure: Insights From the DETERMINE trials.
J Card Fail
November 2024
BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address:
Article Synopsis
- Wearable accelerometers provide a way to continuously monitor physical activity in patients with heart failure, which could be useful for assessing treatment effects.
- In the DETERMINE trials, a subgroup of patients wore accelerometers at different points while also completing questionnaires and walking tests to evaluate their functional status.
- Results showed that lower activity levels were associated with worse health scores and measures, but overall, the relationships between accelerometer data and health assessments were generally weak, suggesting accelerometers could offer additional insights beyond traditional methods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!