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Is there a risk of esketamine misuse in clinical practice?
Ther Adv Drug Saf
January 2025
Pharmacology Department, School of Medicine, University of Valladolid, Valladolid, Spain.
In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years.
View Article and Find Full Text PDFThe use of cannabidiol as adjunctive therapy in adult patients with drug-resistant epilepsy: a systematic review and meta-analysis.
Ther Adv Neurol Disord
January 2025
Department of Neurology, Neurological Intensive Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, Member of the European Reference Network EpiCARE, Salzburg, Austria.
Background: Highly purified cannabidiol (CBD), recently approved for various neurological disorders, is explored as a potential therapeutic avenue for drug-resistant epilepsy (DRE) among adult people with epilepsy (PWE) in this systematic review and meta-analysis.
Objectives: To conduct an extensive literature review and meta-analysis of CBD use for DRE in adult PWE.
Design: Systematic review and meta-analysis.
Epidemiology, Clinical Characteristics and Treatment Outcomes of Infection at a Regional Hospital in Thailand.
Infect Drug Resist
January 2025
Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Objective: This retrospective cohort study evaluated the treatment outcome of infection.
Methods: In this retrospective cohort study, 476 patients with () infection who were admitted to the internal medicine ward at Lampang Hospital, Lampang, Thailand, from 1 January 2020 to 31 December 2020 were enrolled. Medical records were reviewed.
Successful Treatment of Cutaneous Mycobacterium chelonae Infection in an Immunocompromised Patient Using Moxifloxacin and Clarithromycin.
Cureus
December 2024
Department of Infectious Diseases, University of Tsukuba Hospital, Tsukuba, JPN.
is a ubiquitous organism classified as a nontuberculous mycobacterium that rarely causes indolent skin or soft-tissue infections, especially in immunocompromised patients. Given the rarity of infection, diagnosis can be difficult because cutaneous lesions may be considered a worsening of the underlying disease or a benign condition. Here, we report a case of a rapidly progressing cutaneous infection in a patient with nephrotic syndrome.
View Article and Find Full Text PDFOvercoming Recurrent Isolated Sleep Paralysis: A Case Report of Integrative Management With Yoga, Meditation, and Vitamin D3 Supplementation.
Cureus
December 2024
Community Medicine, Terna Medical College, Navi Mumbai, IND.
Recurrent isolated sleep paralysis (RISP) is a rare but distressing condition characterized by episodes of temporary immobility during transitions between wakefulness and sleep. This report describes a 30-year-old female presenting frequently with nightmares, sleep paralysis, and associated stress, successfully managed with a holistic approach incorporating yoga, meditation, chanting, and vitamin D3 supplementation. The patient's significant history of osteoporosis (in February 2019, bone density T-score <-2.
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