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Pyrrolo[2,1-][1,2,4]triazine () is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound was produced through a newly developed synthetic methodology utilizing simple building blocks such as pyrrole, chloramine, and formamidine acetate by examining the mechanistic pathway for the process optimization exercise. Triazine was obtained in 55% overall yield in a two-vessel-operated process. This work describes the safety of the process, impurity profiles and control, and efforts toward the scale-up of triazine for the preparation of kilogram quantity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787819 | PMC |
| http://dx.doi.org/10.1021/acs.oprd.1c00071 | DOI Listing |
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