Helicity, a measure of the breakage of reflectional symmetry representing the topology of turbulent flows, contributes in a crucial way to their dynamics and to their fundamental statistical properties. We review several of their main features, both new and old, such as the discovery of bi-directional cascades or the role of helical vortices in the enhancement of large-scale magnetic fields in the dynamo problem. The dynamical contribution in magnetohydrodynamic of the cross-correlation between velocity and induction is discussed as well. We consider next how turbulent transport is affected by helical constraints, in particular in the context of magnetic reconnection and fusion plasmas under one- and two-fluid approximations. Central issues on how to construct turbulence models for non-reflectionally symmetric helical flows are reviewed, including in the presence of shear, and we finally briefly mention the possible role of helicity in the development of strongly localized quasi-singular structures at small scale. This article is part of the theme issue 'Scaling the turbulence edifice (part 2)'.
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http://dx.doi.org/10.1098/rsta.2021.0087 | DOI Listing |
Front Mol Biosci
January 2025
Center for Biomolecular and Cellular Structure, Institute for Basic Science, Daejeon, Republic of Korea.
Huntington's disease (HD) is primarily caused by the aberrant aggregation of the N-terminal exon 1 fragment of mutant huntingtin protein (mHttex1) with expanded polyglutamine (polyQ) repeats in neurons. The first 17 amino acids of the N-terminus of Httex1 (N17 domain) immediately preceding the polyQ repeat domain are evolutionarily conserved across vertebrates and play multifaceted roles in the pathogenesis of HD. Due to its amphipathic helical properties, the N17 domain, both alone and when membrane-associated, promotes mHttEx1 aggregation.
View Article and Find Full Text PDFMol Phys
March 2024
Department of Physics, Brooklyn College of the City University of New York, Brooklyn, NY 11210, United States.
The stability of proteins and small peptides depends on the way they interact with the surrounding water molecules. For small peptides, such as -helical polyalanine (polyALA), water molecules can weaken the intramolecular hydrogen-bonds (HB) formed between the peptide backbone O and NH groups which are responsible for the -helix structure. Here, we perform molecular dynamics simulations to study the hydration of polyALA, polyserine (polySER), and other homopolymer peptide -helices at different temperatures and pressures.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Purpose: To evaluate the safety and efficacy of Helical Tomotherapy stereotactic body radiotherapy (HT-SBRT) in treating multiple primary lung cancers (MPLCs) and second primary lung cancer (SPLC).
Methods: From January 2010 to September 2023, 106 MPLCs and SPLC (T1-3N0M0) underwent HT-SBRT. The cumulative incidence for local recurrence (LR) was calculated using the competing risk approach and compared using Gray's test.
Nat Commun
January 2025
NMR-based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Membrane bound histidine kinases (HKs) are ubiquitous sensors of extracellular stimuli in bacteria. However, a uniform structural model is still missing for their transmembrane signaling mechanism. Here, we used solid-state NMR in conjunction with crystallography, solution NMR and distance measurements to investigate the transmembrane signaling mechanism of a paradigmatic citrate sensing membrane embedded HK, CitA.
View Article and Find Full Text PDFNat Mater
January 2025
Department of Physics, Harvard University, Cambridge, MA, USA.
Atomically thin van der Waals (vdW) films provide a material platform for the epitaxial growth of quantum heterostructures. However, unlike the remote epitaxial growth of three-dimensional bulk crystals, the growth of two-dimensional material heterostructures across atomic layers has been limited due to the weak vdW interaction. Here we report the double-sided epitaxy of vdW layered materials through atomic membranes.
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