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Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas.
Int J Cancer
March 2025
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Article Synopsis
- Filamin A (FLNA) is found at lower levels in adrenocortical carcinomas (ACC) compared to adenomas (ACA), and its presence is linked to less aggressive tumor behavior due to its role in regulating IGF1R signaling.
- The study investigated the expression of Wee1 kinase in ACC and how it is influenced by FLNA, revealing increased Wee1 and decreased FLNA proteins in ACC, along with insights into the effects of the Wee1 inhibitor AZD1775.
- Findings indicate that FLNA promotes the degradation of Wee1, and that low FLNA levels in ACC lead to heightened Wee1, suggesting that targeting Wee1 with inhibitors could be a promising treatment strategy for FLNA-deficient
Meibomian gland lipid alterations and ocular surface sequela in Awat2 knockout murine model of meibomian gland dysfunction and evaporative dry eye disease.
Ocul Surf
October 2024
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, 95616, USA; Department of Ophthalmology and Vision Science, School of Medicine, University of California-Davis, Davis, CA, 95616, USA. Electronic address:
Article Synopsis
- There is a need for better animal models to study meibomian gland dysfunction (MGD) and evaporative dry eye disease (EDED), leading researchers to evaluate Awat2 knockout (KO) mice for this purpose.
- The study involved various tests on both wildtype and Awat2 KO mice, including ocular examinations, lipid analysis, and gene expression assessments.
- Results showed that Awat2 KO mice exhibited characteristics similar to human MGD and EDED, such as corneal issues and impaired meibum secretion, making them suitable for testing new treatments.
Genetically surface-modified outer membrane vesicles targeting MUC1 antigen in cancer cells.
Biotechnol Rep (Amst)
December 2024
Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Outer membrane vesicles (OMVs), non-replicating spherical liposomes derived from Gram-negative bacteria, are a promising vaccine platform and multifunctional delivery systems. Their ability to be modified via genetic engineering for the incorporation and display of heterologous proteins enhances their functionality. In this study, we demonstrated a bio-ligation approach to display single-chain variable fragments (scFv) on the OMV surface using the SpyTag/SpyCatcher system.
View Article and Find Full Text PDFSMARCB1-Retained and SMARCB1-Deficient SNUC are Genetically Distinct: A Pilot Study Using RNA Sequencing.
J Neurol Surg B Skull Base
August 2024
Department of Otolaryngology and Head and Neck Surgery, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania, United States.
Understanding the genetic basis for the molecular classification of sinonasal undifferentiated carcinoma (SNUC) based on SMARCB1 may improve our understating regarding the nature of the disease. The objective of the study was to compare the genetic profile of SMARCB1-retained (SR-SNUC) and SMARCB1-deficient SNUC (SD-SNUC). Formalin-fixed, paraffin-embedded tissue from treatment-naive patients with SNUC were selected.
View Article and Find Full Text PDFGrainyhead-like 2 Deficiency and Kidney Cyst Growth in a Mouse Model.
J Am Soc Nephrol
July 2024
Molecular and Translational Kidney Research, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Key Points: Our study reveals segment-specific mechanisms in cystic kidney disease and suggests as a modifier of collecting duct–derived cyst progression. Our data demonstrate that genetic deletion of accelerates disease progression in a cystic mouse model.
Background: The transcription factor grainyhead-like 2 (GRHL2) plays a crucial role in maintaining the epithelial barrier properties of the kidney collecting duct and is important to osmoregulation.
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