AI Article Synopsis
- - Maternal immune activation (MIA) using high molecular weight poly(I:C) is a method to study schizophrenia and autism in preclinical research, but variations in the technique can lead to different results.
- - In experiments with Wistar rats, administering 4 mg/kg of HMW-poly(I:C) on GD19 resulted in maternal sickness, smaller litter sizes, and increased levels of serum cytokines.
- - The study found that male offspring had higher serum cytokine levels compared to females, while MIA didn't change peripheral cytokines in either sex, which can help better understand neurodevelopmental disorders.
Article Abstract
Maternal immune activation (MIA) with poly(I:C) is a preclinical paradigm for schizophrenia and autism research. Methodological variations, including poly(I:C) molecular weight, contribute to inconsistencies in behavioural and molecular outcomes. We established in Wistar rats that 4 mg/kg high molecular weight (HMW)-poly(I:C) on GD19 induces maternal sickness, smaller litters and maternal elevations of serum cytokines, including increases in monocyte chemoattractants. In adult offspring, we found that males have higher serum cytokines than females, and MIA did not alter peripheral cytokines in either sex. Our study will contribute to the effective use of the MIA model to elucidate the neurobiology of neurodevelopmental disorders.
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| http://dx.doi.org/10.1016/j.jneuroim.2022.577813 | DOI Listing |
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