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Discovery of Novel Thiazolohydrazone Derivatives as an Alternative Option in the Treatment of Zoonotic Toxocara canis: In Vitro and In Silico Evaluation.
Vet Med Sci
January 2025
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
Thiazoles serve as pharmacophores in many molecules that exhibit significant biological activity. This study used in vitro assays and in silico methodologies to identify novel medication candidates for preclinical evaluation of visceral toxocariasis treatment. The objective was to assess the impact of 11 thiazolohydrazone derivative compounds on the larval eggs of Toxocara canis.
View Article and Find Full Text PDFSilver Nanoparticles from : Evaluation of Potential Ovicidal Activity on Eggs.
Pathogens
November 2024
Laboratório de Parasitologia Experimental e Controle Biológico, Universidade Vila Velha, Rua São Joao, 48, Vila Velha 29101-420, ES, Brazil.
The filtrate of the nematophagous fungus produces silver nanoparticles (AgNPs) with nematicidal potential. However, there are currently no reports of its activity against eggs. The aim of this study was to investigate the potential ovicidal activity of AgNPs- on eggs.
View Article and Find Full Text PDFAssociation of Neuroblastoma (NB) SH-SY5Y Cells with Antibodies of Parasitic Origin (Anti- and Anti-).
Int J Mol Sci
December 2024
Laboratorio de Investigación en Parasitología, Hospital Infantil de México Federico Gómez (HIMFG), Dr. Márquez 162. Col Doctores, Cuauhtémoc, México City 06720, Mexico.
It is little known that trophozoites and eggs can reduce tumors in vitro and animal models. Although this has been known for many years, the mechanism that induces the antitumor effect in these parasites is still not known. We employed Western blot (WB) and immunofluorescence (IFC) by confocal microscopy to explore the potential protein binding between neuroblastoma (NB) SH-SY5Y cells and anti- and anti- antibodies.
View Article and Find Full Text PDF, the causative agent of zoonotic toxocariasis in humans, is a parasitic roundworm of canids with a complex lifecycle. While macrocyclic lactones (MLs) are successful at treating adult infections when used at FDA-approved doses in dogs, they fail to kill somatic third-stage larvae. In this study, we profiled the transcriptome of third-stage larvae derived from larvated eggs and treated with 10 µM of the MLs - ivermectin and moxidectin with Illumina sequencing.
View Article and Find Full Text PDFEvaluation of a 70 kDa Excreted/Secreted Coproantigen Immunoassay for the Detection of in Dogs.
Iran J Parasitol
January 2024
Department of Invertebrates Zoology, Biological Sciences School, Autonomous University of Nuevo León, San Nicolás de los Garza, Nuevo León, México.
Background: We aimed to develop a sandwich ELISA, using polyclonal antibodies against excretory/secretory (E/S) antigens specific to coproantigens present in -positive dogs.
Methods: Antibodies were produced at Biological Sciences School, Autonomous University of Nuevo León, in 2023 by immunization of rabbits with antigenic extracts from in vitro cultures of larvae. Assays were performed on 100 stool samples from pet dogs, measuring sensitivity, specificity, and cross-reactivity against other parasitic infections.
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