Background: In the horizon of therapeutic restrictions in intracerebral hemorrhage (ICH), recently, non-invasive transcranial electrical stimulation (tES) has achieved considerable prosperities. Translational studies have postulated that transcranial direct current stimulation (tDCS) and the other types of tES remain potentially a novel therapeutic option to reverse or stabilize cognitive and motor impairments.
Objective: The aim of this study was to comparatively evaluate the effects of the four main paradigms of tES, including tDCS, transcranial alternating (tACS), pulsed (tPCS), and random noise (tRNS) stimulations on collagenase-induced sensorimotor impairments and striatum tissue damage in male rats.
Methods: To induce ICH, 0.5 μl of collagenase was injected into the right striatum of male Sprague Dawley rats. One day after surgery, tES, was applied to the animals for seven consecutive days. Motor functions were appraised by neurological deficit score, rotarod, and wire hanging tests on the day before surgery and postoperative days 3, 7, and 14. After behavioral tests, brain tissue was prepared appropriately to perform the stereological evaluations.
Results: The results indicated that the application of the four tES paradigms (tDCS, tACS, tRNS, and tPCS) significantly reversed motor disorders in collagenase-induced ICH groups. Further, the motor function improvement of tACS and tRNS receiving rats in wire-hanging and rotarod tests were higher than the other two tES receiving groups. Structural changes and stereological assessments also confirmed the results of behavioral functions.
Conclusion: Our findings suggest that in addition to tDCS application in the treatment of ICH, other tES paradigms, especially tACS and tRNS may be considered as add-on therapeutic strategies in stroke.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8801075 | PMC |
| http://dx.doi.org/10.1186/s12868-022-00689-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Noninvasive Brain Stimulation for Improving Cognitive Deficits and Clinical Symptoms in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.
Brain Sci
December 2024
Faculty of Psychology, Southwest University, Chongqing 400715, China.
: Noninvasive brain stimulation (NIBS) is a promising complementary treatment for attention-deficit/hyperactivity disorder (ADHD). However, its efficacy varies due to diverse participant profiles and methodologies. This meta-analysis, registered with PROSPERO (CRD42023457269), seeks to assess NIBS efficacy in improving cognitive deficits and clinical symptoms in individuals with ADHD.
View Article and Find Full Text PDFNon-invasive brain stimulation in research and therapy.
Sci Rep
November 2024
Department of Psychology and Human Development, IOE, UCL's Faculty of Education and Society, University College London, London, UK.
Since the introduction of transcranial magnetic stimulation (TMS) almost four decades ago, non-invasive brain stimulation (NIBS) techniques have emerged as promising tools to study brain-behaviour relationships in healthy and impaired states with unprecedented precision. Various NIBS techniques, including TMS, transcranial direct current stimulation (tDCS), and emerging methods such as transcranial alternating current stimulation (tACS) and transcranial random noise stimulation (tRNS) are employed in both research and clinical settings. TMS has gained regulatory approval for treating conditions like major depressive disorder and migraine, while tDCS is showing efficacy in enhancing cognitive functions in various populations.
View Article and Find Full Text PDFDaily high-frequency transcranial random noise stimulation (hf-tRNS) for sleep disturbances and cognitive dysfunction in patients with mild vascular cognitive impairments: A study protocol for a pilot randomized controlled trial.
PLoS One
October 2024
Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.
Article Synopsis
- Poor sleep quality is linked to cerebrovascular diseases, which can lead to cognitive decline and strokes as people age, but research on non-drug treatments is limited.
- A study will involve Chinese participants aged 60-90 with mild vascular cognitive impairment and sleep issues, who will be assigned to different stimulation groups (hf-tRNS, tACS, or sham) over two weeks while their brain activity is monitored.
- The study aims to evaluate the safety, feasibility, and effectiveness of high-frequency transcranial random noise stimulation (hf-tRNS) to improve cognitive function and sleep quality in these patients.
Glaucoma Rehabilitation Using ElectricAI Transcranial Stimulation (GREAT)-Optimizing Stimulation Protocol for Vision Enhancement Using an RCT.
Transl Vis Sci Technol
September 2024
School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Article Synopsis
- The study assessed the effects of three types of transcranial electrical stimulation (tES) on peripheral vision in glaucoma patients using a double-masked, placebo-controlled approach with 35 participants.
- Results showed that anodal transcranial direct current stimulation (a-tDCS) significantly improved visual detection accuracy and electrophysiological measures (signal-to-noise ratio and latency) compared to sham stimulation, while other tES methods (tACS and tRNS) did not show significant improvements.
- The findings indicate a-tDCS can enhance vision measures in glaucoma patients, but the overall changes observed were minimal, suggesting further research is needed to explore its effectiveness.
Transcranial Electrical Stimulation: Clinical Implication and Practice for Treatment of Psychiatric Illness.
Clin Psychopharmacol Neurosci
August 2024
Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Korea.
Brain electrical stimulation, particularly non-invasive brain stimulation (NIBS) techniques such as transcranial electrical stimulation (tES), have emerged as a promising treatment for various psychiatric disorders, including depression, anxiety, and post-traumatic stress disorder. tES techniques, such as transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial random noise stimulation (tRNS), are cost-effective and safe interventions that are designed to affect neuronal circuits in the brain using various modalities. Although tES has shown effectiveness in the treatment of psychiatric disorders, there is a lack of comprehensive papers that consider its clinical implications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!