AI Article Synopsis
- Serum Sur1 levels are significantly elevated in patients with moderate to severe traumatic brain injury (TBI) compared to healthy controls.
- There is a strong correlation between serum Sur1 concentrations and measures of traumatic severity, such as Glasgow coma scale (GCS) and Rotterdam CT classification, as well as clinical outcomes (GOS score) after 3 months.
- Higher serum Sur1 levels are linked to unfavorable outcomes, suggesting that it could serve as a reliable prognostic biomarker for TBI.
Article Abstract
Background: Sulfonylurea receptor-1 (Sur1) plays an important role in acute brain injury. We determine whether serum Sur1 concentrations are associated with traumatic severity and clinical outcome after traumatic brain injury (TBI).
Methods: Serum Sur1 concentrations were measured in 100 healthy controls and 138 patients with moderate to severe TBI. Glasgow coma scale (GCS) and Rotterdam computed tomography (CT) classification were recorded to assess traumatic severity. Glasgow outcome scale (GOS) score of 1-3 at posttraumatic 3 months was defined as an unfavorable outcome.
Results: Serum Sur1 concentrations were markedly higher in patients than in controls. Serum Sur1 concentrations of patients were highly correlated with GCS score, Rotterdam CT classification and GOS score. Patients with unfavorable outcome displayed markedly higher serum Sur1 concentrations than those presenting with favorable outcome. Under receiver operating characteristic curve, serum Sur1 concentrations significantly distinguished patients at risk of unfavorable outcome. Serum Sur1 emerged as an independent predictor for unfavorable outcome.
Conclusions: Rising serum Sur1 concentrations are highly correlated with traumatic severity and are independently associated with poor prognosis after TBI, indicating that serum Sur1 may have the potential to be a useful prognostic biomarker of TBI.
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| http://dx.doi.org/10.1016/j.cca.2022.01.018 | DOI Listing |
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