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A 12-chemokine gene signature is associated with the enhanced immunogram scores and is relevant for precision immunotherapy. | LitMetric

A 12-chemokine gene signature is associated with the enhanced immunogram scores and is relevant for precision immunotherapy.

Med Oncol

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Published: January 2022

AI Article Synopsis

  • * The study identified a 12-chemokine TLS (tertiary lymphoid structures) signature that correlates with improved immune features and increased tumor mutation burden in the tumor microenvironment, indicating a potentially expanded immune activation status.
  • * Validation of the 12-chemokine TLS signature across multiple datasets shows its potential as a predictive and prognostic biomarker for immunotherapy effectiveness, particularly in melanoma and bladder cancer.

Article Abstract

Advances in the understanding of checkpoint blockade immunotherapy have suggested that boosting the cancer-immunity cycle (CIC) can help induce regression of tumors. However, good efficacy only occurs in a subset of patients. Predictive biomarkers that can reflect the tumor microenvironment (TME) and CIC may have great potential. More recently, the presence of intratumoral tertiary lymphoid structures (TLSs) has also been correlated with clinical benefit in patients. In this study, we comprehensively measured the immunogram scores (IGSs) for the CIC and explored the associations between immunological and mutational features and a 12-chemokine metagene TLS signature in data from The Cancer Genome Atlas (TCGA). Three immunotherapy datasets were further applied for validation. In the TCGA dataset, we observed that the 12-chemokine TLS signature score was positively associated with the enhanced IGSs as represented by increased tumor mutational burden (TMB) and neoantigen burden (TNB), enriched immune cell (IC) infiltration, and elevated cytolytic activity and checkpoint expression. Specifically, in bladder cancer and melanoma, the high 12-chemokine TLS signature score was found to potentially reflect an expanded cancer-immunity status characterized by high TNB and an immune-inflamed feature. The predictive and prognostic value of the 12-chemokine TLS signature was further validated in several immunotherapy datasets. The score of the 12-chemokine TLS signature may serve as a pancancer marker of the immune-active phenotype. The 12-chemokine TLS signature showed promise as a predictive and prognostic biomarker for ICB efficacy, especially in melanoma and bladder cancer.

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Source
http://dx.doi.org/10.1007/s12032-021-01635-2DOI Listing

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