Evaluation of liver T and T values in acute liver inflammation models using 7T-MRI.

Purpose: We measured the T and T values the liver of acute liver inflammation model mice administered carbon tetrachloride (CCl) after 3 days and 6 days after dispensed, and we compared and examined whether each relaxation time can be used for detect acute liver inflammation.

Methods: To create an acute liver inflammation model, a mixture of 0.2 ml / 100 g of CCl with an equal amount of Sesame Oil was administered once intraperitoneally to C57BL / 6JJmsSlc mice (n = 15). On the 3 days and 6 days after administration, we acquired T mapping images and T mapping images of the liver under respiratory synchronization using for preclinical 7T-MRI, and we measured T and T values and compared statistically.

Results: The liver T value of control mice was 33.9 ± 2.5 ms before CCl administration, 43.2 ± 4.9 ms (p < 0.01) on the 3 days post CCl injection, and 41.0 ± 1.2 ms (p < 0.001) on the 6 days post CCl injection. The rate showed a significant increase of 27% on the 3 days after, as well as significant increase of 21% on the 6 days after. On the other hand, the liver T value of control mice was 26.7 ± 1.9 ms before CCl administration, 31.5 ± 3.4 ms (p < 0.05) 3 days post CCl injection, and 29.0 ± 2.0 ms (p = 0.06) 6 days post CCl injection. The rate 3 days after CCl administration showed a significant increase of 18%, after 6 days rate increased 9%, but no significant difference was confirmed compared with normal mice.

Conclusions: The T value changed significantly compared to the T value, and a continuous change was observed even after 6 days. T mapping can diagnose acute liver inflammation.