AI Article Synopsis

  • Young adults with type 1 diabetes (T1D) have a reported vertebral fracture (VF) prevalence that may reach up to 24%, raising the question of whether they need preventive screening.
  • A study compared the prevalence of VFs between 127 adults with T1D and 65 nondiabetic controls, assessing factors like bone density and turnover markers.
  • The findings indicated that VF prevalence was similar between the two groups (2.4% for T1D vs 3.1% for controls), suggesting no increased risk of VFs in individuals with relatively well-controlled T1D.

Article Abstract

Context: Vertebral fracture (VF) prevalence up to 24% has been reported among young people with type 1 diabetes (T1D). If this high prevalence is confirmed, individuals with T1D could benefit from preventative VF screening.

Objective: We compared the prevalence of VFs between adults with T1D and nondiabetic controls.

Methods: This cross-sectional study included 127 adults with T1D, and 65 controls with a similar age, sex, and BMI distribution, from outpatient clinics of 2 tertiary care centers. Vertebral fracture assessment (VFA) by dual-energy x-ray absorptiometry (DXA) was used for prevalent VFs. The modified algorithm-based qualitative (mABQ) method was applied. Bone mineral density (BMD) and trabecular bone score (TBS) were assessed by DXA. Serum bone turnover markers and sclerostin were measured in a subgroup of participants.

Results: Participants with T1D (70 women, 57 men) had a mean age of 42.8 ± 14.8 years, median diabetes duration of 25.8 (15.8-34.4) years, mean BMI of 26.6 ± 5.4 kg/m2 and mean HbA1c over the past 3 years of 7.5 ± 0.9%. Controls (35 women, 30 men) had mean age of 42.2 ± 15.9 years and mean BMI of 26.1 ± 5.1 kg/m2. VF prevalence was comparable between groups (2.4% vs 3.1%, P = 0.99). TBS, BMD at the total hip and femoral neck, and bone formation and resorption markers were lower while sclerostin levels were similar in participants with T1D vs controls.

Conclusion: Our VFA results using the mABQ method do not confirm increased prevalence of VFs in men and women with relatively well-controlled T1D.

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Source
http://dx.doi.org/10.1210/clinem/dgac031DOI Listing

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