Alzheimer's disease (AD) is a neurodegenerative disease that is coupled with chronic cognitive dysfunction. AD cases are mostly late onset, and genetic risk factors like the Apolipoprotein E () play a key role in this process. 2, 3, and 4 are three key alleles in the human gene. For late onset, 4 has the most potent risk factor while 2 plays a defensive role. Several studies suggests that 4 causes AD via different processes like neurofibrillary tangle formation by amyloid-β accumulation, exacerbated neuroinflammation, cerebrovascular disease, and synaptic loss. But the pathway is still unclear that which actions of 4 lead to AD development. Since was found to contribute to many AD pathways, targeting 4 can lead to a hopeful plan of action in development of new drugs to target AD. In this review, we focus on recent studies and perspectives, focusing on 4 as a key molecule in therapeutic strategies.
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| http://dx.doi.org/10.3233/ADR-210027 | DOI Listing |
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