Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.

J Oral Microbiol

Department of Biochemistry and Molecular Biology, Institute for Biotechnology and Biomedicine (BIOTECMED), University of Valencia, Valencia, Spain.

Published: January 2022

Background: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.

Aim Of The Study: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.

Methods: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.

Results: Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes.

Conclusion: Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788378PMC
http://dx.doi.org/10.1080/20002297.2022.2030094DOI Listing

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