Background: SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.
Aim Of The Study: To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.
Methods: SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.
Results: Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes.
Conclusion: Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.
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http://dx.doi.org/10.1080/20002297.2022.2030094 | DOI Listing |
J Immunotoxicol
December 2024
Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic products, and cleaning solutions. Yet, there is minimal published data on CPC effects on eukaryotes, immune signaling, and human health. Previously, it was shown that low-micromolar CPC inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca mobilization, microtubule polymerization, and degranulation.
View Article and Find Full Text PDFDent Mater J
January 2025
Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University.
In dental practice, there are two major diseases: dental caries and periodontal disease. Although dental treatment techniques have advanced along with advances in dental materials, some diseases such as root surface caries and horizontal bone resorption have not yet achieved satisfactory treatment results. Since these diseases are infections caused by oral bacteria, we believe that materials with long-lasting antimicrobial properties would help control these diseases.
View Article and Find Full Text PDFCureus
December 2024
Department of Prosthodontics, Graduate School of Dentistry, Showa University, Tokyo, JPN.
Purpose This study aimed to evaluate the effectiveness of cetylpyridinium chloride (CPC) mouthwash in reducing denture plaque and its impact on the microbial composition of denture plaque. Materials and methods A randomized, placebo-controlled crossover trial included 29 participants with maxillary complete dentures. Participants used either CPC or a placebo mouthwash for one week each in a crossover design.
View Article and Find Full Text PDFPurpose: To examine the alterations in oral healthcare indicators subsequent to the administration of cetylpyridinium chloride.
Materials And Methods: In this retrospective study, clinical data of 58 patients who received orthodontic treatment using removable appliances at our medical facility were collected. Patients were divided into two groups based on whether they used cetylpyridinium chloride during orthodontic treatment: the combined group (n = 31, received 0.
Microorganisms
December 2024
Oral Care Product Development, The Procter & Gamble Company, Cincinnati, OH 45202, USA.
Various ingredients are utilized to inhibit the growth of harmful bacteria associated with cavities, gum disease, and bad breath. However, the precise mechanisms by which these ingredients affect the oral microbiome have not been fully understood at the molecular level. To elucidate the molecular mechanisms, a high-throughput bacterial transcriptomics study was conducted, and the gene expression profiles of six common oral bacteria, including two Gram-positive bacteria (, ) and four Gram-negative bacteria (, , , and ), were analyzed.
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