Evolution of FMT - From early clinical to standardized treatments.

Biologicals

International Alliance for Biological Standardization, IABS, Geneva, Switzerland. Electronic address:

Published: April 2022

AI Article Synopsis

  • - Faecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridioides difficile infections and is being explored for other conditions like inflammatory bowel disease and cancer.
  • - New guidelines are being developed to address technical and logistical challenges in implementing FMT as a non-standardized treatment in clinical settings.
  • - A joint online workshop by the International Alliance for Biological Standardization and BIOASTER in May 2021 brought together experts to discuss the creation of comprehensive FMT guidelines covering technical, regulatory, and standardization aspects.

Article Abstract

Faecal microbiota transplantation (FMT) is widely reported to be an effective treatment against recurrent Clostridioides difficile infections. Recent clinical studies support the therapeutic use of FMT for several other pathologies including inflammatory bowel disease, several types of cancer, and other functional or metabolic disorders. Initial guidelines are now available to overcome some of the technical and logistical issues for establishing a non-standardized treatment into clinical practice with proper safety and governance. To aid the improvement of guidance and standardization requirements for FMT, the International Alliance for Biological Standardization (IABS) and the BIOASTER Microbiology Technology Institute hosted a joint online workshop in May of 2021. The goal of the webinar was to provide a multi-disciplinary perspective of the ongoing efforts to develop FMT guidelines including technical, regulatory, and standardization requirements. Recognized experts gave insights into state-of-the art approaches and standards developed by international organizations and institutions.

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Source
http://dx.doi.org/10.1016/j.biologicals.2022.01.004DOI Listing

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