AI Article Synopsis
- Surgical interventions in the head and neck can affect how ischemic changes occur in the brain, impacting both their nature and location.
- The review focuses on comparing the timing of basic cellular and molecular processes involved in these changes.
- Criteria for selecting animal models include oxidative stress in brain cells, blood-brain barrier issues, glial activation, neuroinflammation, changes in blood vessel growth, and the model's reproducibility.
Article Abstract
Various surgical interventions into the head and neck vasculature differentially impact nature, localization and dynamics of ischemic changes in the brain structures. In this regard, our review aims to compare the time course of basic cellular and molecular mechanisms. Selection of a animals model should be done along the following criteria: development of oxidative stress in brain cells, blood-brain barrier breakdown, glial activation and neuroinflammation, alterations in angiogenesis; reproducibility of the model.
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| http://dx.doi.org/10.1016/j.tice.2021.101715 | DOI Listing |
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