AI Article Synopsis
- Induced pluripotent stem cells (iPSCs) are promising for regenerative medicine and can be derived from umbilical cord blood (UCB) cells, which are abundant and have low immune rejection rates.
- CD34-UCB cells specifically from the group O/D-negative blood type were reprogrammed to create universal iPSCs for generating red blood cells (RBCs).
- The newly formed iPSCs display characteristics of pluripotent stem cells, paving the way for advanced therapies, particularly in blood transfusion.
Article Abstract
Induced pluripotent stem cells (iPSCs) hold great promise as a potential source for regenerative medicine. Umbilical cord blood (UCB) cells possess a high level of stem cells, exhibit less immune rejection, and have fewer DNA mutations and, thus, are an easily accessible and valuable cell source for iPSC generation for basic research and clinical applications. Here, we reprogrammed CD34-UCB cells with the group O/D-negative (RhD) blood type as a universal source for red blood cell (RBC) generation. The resulting iPSCs, with features typical of pluripotent stem cells, will further advance the development of various therapeutics, including blood transfusion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.scr.2022.102674 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!