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STAT3 in acute myeloid leukemia facilitates natural killer cell-mediated surveillance.
Front Immunol
July 2024
Division Pharmacology, Department of Pharmacology, Physiology and Microbiology, Karl Landsteiner University of Health Sciences, Krems, Austria.
Acute myeloid leukemia (AML) is a heterogenous disease characterized by the clonal expansion of myeloid progenitor cells. Despite recent advancements in the treatment of AML, relapse still remains a significant challenge, necessitating the development of innovative therapies to eliminate minimal residual disease. One promising approach to address these unmet clinical needs is natural killer (NK) cell immunotherapy.
View Article and Find Full Text PDFSTAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response.
Leukemia
May 2024
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hematopoietic stem and progenitor cells (HSPCs) maintain blood-forming and immune activity, yet intrinsic regulators of HSPCs remain elusive. STAT3 function in HSPCs has been difficult to dissect as Stat3-deficiency in the hematopoietic compartment induces systemic inflammation, which can impact HSPC activity. Here, we developed mixed bone marrow (BM) chimeric mice with inducible Stat3 deletion in 20% of the hematopoietic compartment to avoid systemic inflammation.
View Article and Find Full Text PDFEpidermal keratinocyte-specific STAT3 deficiency aggravated atopic dermatitis-like skin inflammation in mice through TSLP upregulation.
Front Immunol
December 2023
Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Article Synopsis
- - Atopic dermatitis (AD) is a common inflammatory skin disease linked to issues like skin barrier dysfunction and immune system dysregulation, with STAT3 playing a key role in skin cell function.
- - Researchers created a mouse model with specific loss of STAT3 in skin cells, which showed worsened AD-like symptoms after exposure to a skin irritant, indicating a negative impact on skin health and microbiome composition.
- - The study found that mice with STAT3 deficiency exhibited more type-2 inflammatory cells and increased levels of TSLP, a protein that attracts immune cells, suggesting that targeting TSLP could help reduce skin inflammation in AD.
Bushen Antai recipe ameliorates immune microenvironment and maternal-fetal vascularization in STAT3-deficient abortion-prone mice.
J Ethnopharmacol
January 2024
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Ethnopharmacological Relevance: Spontaneous abortion (SA) is an intricate disorder affecting women of reproductive age. Previous studies have confirmed the indispensable role of signal transducer and activator of transcription (STAT) 3 in normal pregnancy. Bushen Antai recipe (BAR) is a satisfactory formula commonly used in practice, based on the rationale of traditional Chinese medicine (TCM) for SA.
View Article and Find Full Text PDFConstant Activation of STAT3 Contributes to the Development of Adenomyosis in Females.
Endocrinology
May 2022
Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Adenomyosis is a benign uterine disease that causes dysmenorrhea, heavy menstrual bleeding, and infertility; however, its pathophysiology remains unclear. Since signal transducer and activator of transcription 3 (STAT3) is crucial for endometrial regeneration, we hypothesized that STAT3 participates in adenomyosis pathophysiology. To investigate the influence of STAT3 on adenomyosis development, this study was performed using a novel mouse model of adenomyosis and human specimens of eutopic endometria and adenomyosis lesions.
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