Monocytes as a convergent nanoparticle therapeutic target for cardiovascular diseases.

Adv Drug Deliv Rev

Department of Chemical Engineering and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address:

Published: March 2022

Due to the increasing population of individuals with cardiovascular diseases and related comorbidities, there is an increasing need for development of synergistic therapeutics. Monocytes are implicated in a broad spectrum of diseases and can serve as a focal point for therapeutic targeting. This review discusses the role of monocytes in cardiovascular diseases and highlights trends in monocyte targets nanoparticles in three cardiovascular-related diseases: Diabetes, Atherosclerosis, and HIV. Finally, the review offers perspectives on how to develop nanoparticle monocyte targeting strategies that can be beneficial for treating co-morbidities.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359644PMC
http://dx.doi.org/10.1016/j.addr.2022.114116DOI Listing

Publication Analysis

Top Keywords

cardiovascular diseases
12
diseases
5
monocytes convergent
4
convergent nanoparticle
4
nanoparticle therapeutic
4
therapeutic target
4
target cardiovascular
4
diseases increasing
4
increasing population
4
population individuals
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!