After a 2-day buildup, patients were dosed continuously with clozapine solution at three ascending dose levels (37.5, 75, and 150 mg bid for 7 days at each dose level). Following the morning administration on the twenty-third day of dosing a drug holiday was instituted which lasted for a minimum of 48 hr. Serial plasma samples were obtained during each of the periods and during the drug holiday for the calculation of the steady-state parameters AUCSS, CSSmax, and CSSmin at each dose level as well as for the assessment of the terminal elimination rate. Mean parameter values for AUCSS, CSSmax, and CSSmin showed a linearly increasing response with the dose, well described by a straight line passing through the origin. The terminal elimination appeared to follow linear kinetics and had a mean half-life of 15.8 hr (range, 5.8-33 hr).

Download full-text PDF

Source
http://dx.doi.org/10.1023/a:1016434312388DOI Listing

Publication Analysis

Top Keywords

dose level
8
drug holiday
8
aucss cssmax
8
cssmax cssmin
8
terminal elimination
8
multiple-dose pharmacokinetics
4
pharmacokinetics clozapine
4
clozapine patients
4
patients 2-day
4
2-day buildup
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!