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Anaphylaxis in infancy: An area that needs to be highlighted.
Allergol Immunopathol (Madr)
January 2025
Department of Pediatrics, University Hospital of Ioannina, Ioannina, Greece.
Anaphylaxis, the most severe end of the spectrum of allergic reactions, has shown increasing incidence globally over recent years. This hypersensitivity reaction can occur at any age, including infancy. Recent data, although scarce, show that anaphylaxis is increasingly reported in infancy, with food identified as the leading cause of anaphylaxis cases in this age group.
View Article and Find Full Text PDFTranscription factor prediction using protein 3D secondary structures.
Bioinformatics
January 2025
Institute for Computational Systems Biology, Universität Hamburg, Hamburg, 22761, Germany.
Motivation: Transcription factors (TFs) are DNA-binding proteins that regulate gene expression. Traditional methods predict a protein as a TF if the protein contains any DNA-binding domains (DBDs) of known TFs. However, this approach fails to identify a novel TF that does not contain any known DBDs.
View Article and Find Full Text PDFSemblans: Automated assembly and processing of RNA-Seq data.
Bioinformatics
January 2025
Department of Biological Sciences, University of Illinois at Chicago, Illinois 60607, United States.
Motivation: Recent advancements in parallel sequencing methods have precipitated a surge in publicly available short-read sequence data. This has encouraged the development of novel computational tools for the de novo assembly of transcriptomes from RNA-seq data. Despite the availability of these tools, performing an end-to-end transcriptome assembly remains a programmatically involved task necessitating familiarity with best practices.
View Article and Find Full Text PDFDevelopment and Validation of a Routine Electronic Health Record-Based Delirium Prediction Model for Surgical Patients Without Dementia: Retrospective Case-Control Study.
JMIR Perioper Med
January 2025
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, United States.
Background: Postoperative delirium (POD) is a common complication after major surgery and is associated with poor outcomes in older adults. Early identification of patients at high risk of POD can enable targeted prevention efforts. However, existing POD prediction models require inpatient data collected during the hospital stay, which delays predictions and limits scalability.
View Article and Find Full Text PDFBayesian Gene Set Benchmark Dose Estimation for "omic" responses.
Bioinformatics
January 2025
Division of Intramural Research, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, North Carolina 27709, United States.
Motivation: Estimating a toxic reference point using tools like the benchmark dose (BMD) is a critical step in setting policy to regulate pollution and ensure safe environments. Toxicity can be measured for different endpoints, including changes in gene expression and histopathology for various tissues, and is typically explored one gene or tissue at a time in a univariate setting that ignores correlation. In this work, we develop a multivariate estimation procedure to estimate the BMD for specified gene sets.
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