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Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2. | LitMetric

AI Article Synopsis

Article Abstract

Neutrophils perform critical functions in the innate response to infection, including through the production of neutrophil extracellular traps (NETs) - web-like DNA structures which are extruded from neutrophils upon activation. Elevated levels of NETs have been linked to autoimmunity but this association is poorly understood. By contrast, IL-17 producing Th17 cells are a key player in various autoimmune diseases but are also crucial for immunity against fungal and bacterial infections. Here we show that NETs, through their protein component histones, directly activate T cells and specifically enhance Th17 cell differentiation. This modulatory role of neutrophils, NETs and their histones is mediated downstream of TLR2 in T cells, resulting in phosphorylation of STAT3. The innate stimulation of a specific adaptive immune cell subset provides an additional mechanism demonstrating a direct link between neutrophils, NETs and T cell autoimmunity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792063PMC
http://dx.doi.org/10.1038/s41467-022-28172-4DOI Listing

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