Child Survival and Early Lifetime Exposures to Ambient Fine Particulate Matter in India: A Retrospective Cohort Study.

Background: Ambient fine particulate matter [PM in aerodynamic diameter ()] is a major health risk for children, particularly in South Asia, which currently experiences the highest levels globally. Nevertheless, there is comparatively little epidemiological evidence from this region to quantify the effects of on child survival.

Objectives: We estimated the association between exposure and child survival in India.

Methods: We constructed a large, retrospective, and nationally representative cohort of children , born between 2009-2016, from the publicly available, cross-sectional 2015-2016 Demographic Health Surveys in India. and post-delivery lifetime average ambient exposures were estimated with data from satellite remote sensing, meteorology, and land use information (model 0.82). We used Cox proportional hazards regression to estimate the association between both average and post-delivery lifetime and all-cause child mortality, controlling for individual- and household-level covariates, seasonality, location, and meteorology.

Results: Over 7,447,724 child-months of follow-up, there were 11,559 deaths at reported by the children's mothers. The mean concentrations of 9-month and post-delivery lifetime average ambient exposure were (range: ) and (range: ), respectively. Estimated child mortality adjusted hazard ratios were 1.023 [95% confidence interval (CI): 1.008, 1.038] and 1.013 (95% CI: 1.001, 1.026) per increase of and post-delivery lifetime , with both exposures in the model.

Discussion: This study adds to the growing body of evidence about the adverse health effects of by demonstrating the association between exposure, both and post-delivery, on child survival at the national level in India. Strategies to reduce ambient air pollution levels, including steps to minimize and early life exposures, are urgently needed in India and other countries where exposures are above recommended guideline values. https://doi.org/10.1289/EHP8910.