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Jinbei oral liquid for idiopathic pulmonary fibrosis: a randomized placebo-controlled trial.
Sci Rep
January 2025
Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
The traditional Chinese medicine compound preparation known as Jinbei Oral Liquid (JBOL) consists of 12 herbs, including Astragalus membranaceus (Fisch.) Bge, Codonopsis pilosula (Franch.) Nannf, et al.
View Article and Find Full Text PDFAdipose-derived mesenchymal stem cells inhibit hepatic stellate cells activation to alleviate liver fibrosis via Hippo pathway.
Stem Cell Res Ther
October 2024
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.
Background: Liver fibrosis is a common pathological process of chronic liver disease, characterized by excessive deposition of extracellular matrix (ECM). Mesenchymal stem cells (MSCs) have been found to have potential therapy effect on liver fibrosis, but the mechanism involved was still unclear. The objective of this study is to investigate the therapeutic efficacy of adipose-derived mesenchymal stem cells (ADMSCs) on the treatment of liver fibrosis, with particular emphasis on elucidating the underlying mechanism of action through which ADMSCs inhibit the activation of hepatic stellate cells (HSCs).
View Article and Find Full Text PDFExtract of (L.) Gaertn Leaves as a Novel Green Corrosion Inhibitor for Carbon Steel in Acidic Solution.
Materials (Basel)
September 2024
School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, China.
In this work, leaves of (L.) Gaertn were extracted by a one-step extraction method using ethanol as a solvent, and the (L.) Gaertn extract (SMGE) was firstly employed as a green corrosion inhibitor for carbon steel in 0.
View Article and Find Full Text PDFBioinformatics analysis based on extracted ingredients combined with network pharmacology, molecular docking and molecular dynamics simulation to explore the mechanism of Jinbei oral liquid in the therapy of idiopathic pulmonary fibrosis.
Heliyon
September 2024
Shandong University of Traditional Chinese Medicine, Jinan, China.
Article Synopsis
- This study investigates Jinbei oral liquid (JBOL) for treating idiopathic pulmonary fibrosis (IPF) and aims to understand its mechanisms by examining target proteins and active components.* -
- Using bioinformatics techniques like network pharmacology and molecular docking, researchers identified 122 targets and 34 compounds, highlighting kaempferol, apigenin, and baicalein as significant.* -
- Key interactions were established between active molecules and target proteins, revealing that pathways such as AGE-RAGE, EGFR, and PI3K-Akt play critical roles in JBOL's effect against IPF.*
Serum SIRT3 levels in epilepsy patients and its association with clinical outcomes and severity: A prospective observational study.
Open Med (Wars)
July 2024
Department of Emergency Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Objective: In this prospective observational study, we aimed to investigate the serum levels of sirtuin (SIRT)3 in epilepsy patients and its association with the severity of the disease.
Methods: This prospective observational study included 203 patients with symptomatic epilepsy and 100 healthy controls who visited our hospital from November 2019 to November 2022. The severity of the disease in epilepsy patients was assessed using the National Hospital Seizure Severity Scale (NHS3).
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