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| http://dx.doi.org/10.1007/s13224-021-01613-8 | DOI Listing |
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Genetic Characterization of HIV-1 Gene from Virologically Controlled Aging Individuals with HIV on Long-Term Antiretroviral Therapy.
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Department of Immunobiology, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Despite advancements in antiretroviral therapy (ART) that reduces the viral load to undetectable levels and improve CD4 T cell counts, viral eradication has not been achieved due to HIV-1 persistence in resting CD4 T-cells. We, therefore, characterized the gene, which is essential for HIV-1 replication and pathogenesis, from 20 virologically controlled aging individuals with HIV (HIV) on long-term ART and improved CD4 T-cell counts, with a particular focus on older individuals. Peripheral blood mononuclear cell genomic DNA from HIV were used to amplify gene by polymerase chain reaction followed by nucleotide sequencing and analysis.
View Article and Find Full Text PDFEnhancing AI reliability: A foundation model with uncertainty estimation for optical coherence tomography-based retinal disease diagnosis.
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Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong 515041, China. Electronic address:
Inability to express the confidence level and detect unseen disease classes limits the clinical implementation of artificial intelligence in the real world. We develop a foundation model with uncertainty estimation (FMUE) to detect 16 retinal conditions on optical coherence tomography (OCT). In the internal test set, FMUE achieves a higher F1 score of 95.
View Article and Find Full Text PDFAccess and coverage of malaria services in Haiti in the context of elimination: a scoping review of the literature.
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Equipe de Recherche sur l'Ecologie des Maladies Infectieuses et Tropicales, Université Quisqueya, Port-au-Prince, Haïti.
Introduction: Haiti is on the verge of possibly eliminating malaria, an endemic parasitic infection primarily caused by Plasmodium falciparum on the island of Hispaniola. Owing to its associated morbidity and mortality, malaria is a leading public health priority in Haiti. This scoping review aims to identify the scope of research on access and coverage of malaria surveillance, diagnosis, and treatment in Haiti in the elimination setting.
View Article and Find Full Text PDFUsing UMAP for Partially Synthetic Healthcare Tabular Data Generation and Validation.
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Intelligent Data Science and Artificial Intelligence Research Center, Technical University of Catalonia, Nexus II Building, Jordi Girona 29, 08034 Barcelona, Spain.
In healthcare, vast amounts of data are increasingly collected through sensors for smart health applications and patient monitoring or diagnosis. However, such medical data often comprise sensitive patient information, posing challenges regarding data privacy, and are resource-intensive to acquire for significant research purposes. In addition, the common case of lack of information due to technical issues, transcript errors, or differences between descriptors considered in different health centers leads to the need for data imputation and partial data generation techniques.
View Article and Find Full Text PDFIt takes a village to raise a child- A multidisciplinary approach to promoting paediatric health literacy in cystic fibrosis.
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Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Belfast, BT9 7AD, Northern Ireland.
Background: In Northern Ireland, approximately 550 people with cystic fibrosis (PwCF) attend the regional paediatric and adult centres within the Belfast Health and Social Care Trust. This autosomal recessive chronic condition necessitates regular clinical monitoring and a high treatment burden, as well as time implications for the maintenance of respiratory devices. Development of health literacy skills at an early age and promoting children with CF (CwCF) to take an active role in their healthcare has many advantages relating to their long-term self-care in preparation for transition from paediatric to adult care, decision-making and partnership engagement with the CF-multidisciplinary team (CF-MDT).
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